公开(公告)号：US09890216B2

公开(公告)日：2018-02-13

申请号：US14437544

申请日：2013-08-30

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： George Georgiou ,  William Kelton ,  Nishant Mehta

IPC: C07K16/30 ,  C07K16/32 ,  C07K16/28 ,  A61K47/48 ,  C07K16/00 ,  A61K47/68

CPC classification number: C07K16/2863 ,  A61K47/6849 ,  C07K16/00 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/56 ,  C07K2317/66 ,  C07K2317/71 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/92

Abstract: Antibody Fc polypeptides are provided that efficiently bind to both Fcγ and Fcα receptors. In certain aspects, a Fc polypeptide comprises a chimeric IgG CH2 domain having a α1 loop from IgA and an IgA CH3 domain. Recombinant antibodies comprising Fc polypeptides of the embodiments and methods for making and using such antibodies are likewise provided.

公开(公告)号：US20150266960A1

公开(公告)日：2015-09-24

申请号：US14437544

申请日：2013-08-30

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： George Georgiou ,  William Kelton ,  Nishant Mehta

IPC: C07K16/28 ,  C07K16/30 ,  A61K47/48 ,  C07K16/00

CPC classification number: C07K16/2863 ,  A61K47/6849 ,  C07K16/00 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/56 ,  C07K2317/66 ,  C07K2317/71 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/92

Abstract: Antibody Fc polypeptides are provided that efficiently bind to both Fcγ and Fcα receptors. In certain aspects, a Fc polypeptide comprises a chimeric IgG CH2 domain having a α1 loop from IgA and an IgA CH3 domain. Recombinant antibodies comprising Fc polypeptides of the embodiments and methods for making and using such antibodies are likewise provided.

Abstract translation: 提供抗体Fc多肽，其有效地结合Fcγ和Fcα受体。 在某些方面，Fc多肽包含具有来自IgA和IgA CH3结构域的α1环的嵌合IgG CH2结构域。 同样提供了包含实施方案的Fc多肽的重组抗体和用于制备和使用这些抗体的方法。