公开(公告)号：US20230399384A1

公开(公告)日：2023-12-14

申请号：US17996874

申请日：2021-04-22

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Zhiqiang KU ,  Ningyan ZHANG ,  Zhiqiang AN ,  Xuping XIE ,  Pei-Yong SHI

IPC: C07K16/10 ,  A61P31/14

CPC classification number: C07K16/1003 ,  A61P31/14 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/34 ,  A61K2039/505

Abstract: Provided herein are antibodies binding to Coronavirus S protein and the uses of the antibodies in detecting and treating Coronavirus infection, such as COVID-19.

公开(公告)号：US20220267415A1

公开(公告)日：2022-08-25

申请号：US17671837

申请日：2022-02-15

Applicant: The Board of Regents of The University of Texas System ,  IGM Biosciences, Inc.

Inventor： Zhiqiang KU ,  Xuping XIE ,  Paul HINTON ,  Ningyan ZHANG ,  Bruce KEYT ,  Dean NG ,  Stephen CARROLL ,  Pei-Yong SHI ,  Zhiqiang AN

IPC: C07K16/10 ,  A61P31/14

Abstract: This disclosure provides multimeric binding molecules that bind to SARS-CoV-2. This disclosure also provides compositions comprising the multimeric binding molecules, polynucleotides that encode the multimeric binding molecules, and host cells that can produce the binding molecules. Further this disclosure provides methods of using the multimeric binding molecules, including methods for treating and preventing coronavirus disease 2019 (COVID-19).