公开(公告)号：US20220267415A1

公开(公告)日：2022-08-25

申请号：US17671837

申请日：2022-02-15

Applicant: The Board of Regents of The University of Texas System ,  IGM Biosciences, Inc.

Inventor： Zhiqiang KU ,  Xuping XIE ,  Paul HINTON ,  Ningyan ZHANG ,  Bruce KEYT ,  Dean NG ,  Stephen CARROLL ,  Pei-Yong SHI ,  Zhiqiang AN

IPC: C07K16/10 ,  A61P31/14

Abstract: This disclosure provides multimeric binding molecules that bind to SARS-CoV-2. This disclosure also provides compositions comprising the multimeric binding molecules, polynucleotides that encode the multimeric binding molecules, and host cells that can produce the binding molecules. Further this disclosure provides methods of using the multimeric binding molecules, including methods for treating and preventing coronavirus disease 2019 (COVID-19).

公开(公告)号：US20230399384A1

公开(公告)日：2023-12-14

申请号：US17996874

申请日：2021-04-22

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Zhiqiang KU ,  Ningyan ZHANG ,  Zhiqiang AN ,  Xuping XIE ,  Pei-Yong SHI

IPC: C07K16/10 ,  A61P31/14

CPC classification number: C07K16/1003 ,  A61P31/14 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/34 ,  A61K2039/505

Abstract: Provided herein are antibodies binding to Coronavirus S protein and the uses of the antibodies in detecting and treating Coronavirus infection, such as COVID-19.

公开(公告)号：US20230068663A1

公开(公告)日：2023-03-02

申请号：US17759800

申请日：2021-01-28

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  IMMUNE-ONC THERAPEUTICS, INC.

Inventor： Zhiqiang AN ,  Ningyan ZHANG ,  Zhiqiang KU ,  Chengcheng ZHANG ,  Xiaoye XU ,  Heyu CHEN ,  JingJing XIE ,  Maria Jose COSTA ,  An SONG ,  X. Charlene LIAO

IPC: C07K16/28 ,  A61K45/06 ,  A61K47/68 ,  A61P35/02 ,  A61K39/395 ,  G01N33/574

Abstract: Provided herein are antibodies binding to LILRB2 and the uses of the antibodies in detecting and treating cancer and autoimmune diseases.

公开(公告)号：US20240383999A1

公开(公告)日：2024-11-21

申请号：US17995214

申请日：2021-04-01

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Ningyan ZHANG ,  Zhiqiang AN ,  Zhiqiang KU ,  Hui DENG ,  Lingegowda S MANGALA ,  Anil K. SOOD

IPC: C07K16/28 ,  A61K39/00

Abstract: Provided herein are anti-CD5L monoclonal antibodies. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer.

公开(公告)号：US20210371508A1

公开(公告)日：2021-12-02

申请号：US17332790

申请日：2021-05-27

Applicant: The Board of Regents of the University of Texas System

Inventor： Ningyan ZHANG ,  Zhiqiang AN ,  Zhiqiang KU ,  Yihong WAN ,  Jing KRZESZINSKI

IPC: C07K16/18 ,  A61K45/06 ,  G01N33/574 ,  A61K47/68

Abstract: Provided herein are methods for treating cancer, such as breast cancer, by administering an inhibitor of NMES1. Further provided herein are NMES1 monoclonal antibodies which may be used to detect or treat cancer.