公开(公告)号：US10980841B2

公开(公告)日：2021-04-20

申请号：US16394312

申请日：2019-04-25

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Bruno Doiron ,  Ralph A Defronzo

IPC: A61K35/39 ,  A61K31/7088 ,  A61K38/17 ,  A61K38/45 ,  C07K14/47 ,  C12N15/113 ,  C12N9/12 ,  C12N9/16 ,  A61K48/00

Abstract: Embodiments of the invention stimulate three levels of beta cell physiology: (i) glucose metabolism, (ii) membrane receptor function, and (iii) transcriptional factors that result in the in vivo formation of beta cells in the pancreas for the purpose of treating diabetes.