公开(公告)号：US20210179687A1

公开(公告)日：2021-06-17

申请号：US16762273

申请日：2018-11-06

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Chengcheng ZHANG ,  Samuel JOHN ,  Heyu CHEN ,  Mi DENG ,  Xun GUI ,  Ningyan ZHANG ,  Zhiqiang AN

IPC: C07K14/705 ,  A61K45/06 ,  A61P35/02 ,  C12N5/0783

Abstract: The present disclosure provides methods and compositions for immunotherapy employing a modified T cell or NK cell comprising a chimeric LILRB4 antigen receptor (CAR) that can be administered to patients for disease (e.g., cancer) treatment.