公开(公告)号：US12161618B2

公开(公告)日：2024-12-10

申请号：US18093840

申请日：2023-01-06

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： James B. Brugarolas ,  Haley Hill ,  Tao Wang

IPC: A61K31/135 ,  A61K31/275 ,  A61P35/00 ,  G01N33/50 ,  A61K45/06

Abstract: The present disclosure provides methods of identifying patients who have partial or total resistance to HIF-2 inhibitors or who develop partial or total resistance to HIF-2 inhibitors after treatment and providing suitable treatment to these patients.

公开(公告)号：US11576889B2

公开(公告)日：2023-02-14

申请号：US17030123

申请日：2020-09-23

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： James B. Brugarolas ,  Haley Hill ,  Tao Wang

IPC: A61K31/135 ,  A61P35/00 ,  A61K31/275 ,  G01N33/50 ,  A61K45/06

Abstract: The present disclosure provides methods of identifying patients who have partial or total resistance to HIF-2 inhibitors or who develop partial or total resistance to HIF-2 inhibitors after treatment and providing suitable treatment to these patients.