公开(公告)号：US12104181B2

公开(公告)日：2024-10-01

申请号：US17710464

申请日：2022-03-31

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： John W. Schoggins ,  Wenchun Fan ,  Daniel J. Siegwart ,  Qiang Cheng

IPC: A61P31/14 ,  A61K9/51 ,  A61K48/00 ,  C12N9/10

CPC classification number: C12N9/104 ,  A61K9/5123 ,  A61K48/0066 ,  A61P31/14

Abstract: Embodiments of the instant disclosure relate to novel antiviral compositions and methods for treating viral infections. In accordance with these embodiments, antiviral compositions can include at least one mRNA encoding for a TRIM7 protein encapsulated into a lipid nanoparticle (LNP). In other embodiments, methods of making antiviral compositions are disclosed as well as methods of administering a composition having at least one mRNA encoding for a TRIM7 protein encapsulated into LNP into a subject.

公开(公告)号：US20220325255A1

公开(公告)日：2022-10-13

申请号：US17710464

申请日：2022-03-31

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： John W. Schoggins ,  Wenchun Fan ,  Daniel J. Siegwart ,  Qiang Cheng

IPC: C12N9/10 ,  A61K48/00 ,  A61K9/51 ,  A61P31/14

Abstract: Embodiments of the instant disclosure relate to novel antiviral compositions and methods for treating viral infections. In accordance with these embodiments, antiviral compositions can include at least one mRNA encoding for a TRIM7 protein encapsulated into a lipid nanoparticle (LNP). In other embodiments, methods of making antiviral compositions are disclosed as well as methods of administering a composition having at least one mRNA encoding for a TRIM7 protein encapsulated into LNP into a subject.

公开(公告)号：US20240401007A1

公开(公告)日：2024-12-05

申请号：US18811649

申请日：2024-08-21

Applicant: The Board of Regents of The University of Texas System

Inventor： John W. Schoggins ,  Wenchun Fan ,  Daniel J. Siegwart ,  Qiang Cheng

IPC: C12N9/10 ,  A61K9/51 ,  A61K48/00 ,  A61P31/14

Abstract: Embodiments of the instant disclosure relate to novel antiviral compositions and methods for treating viral infections. In accordance with these embodiments, antiviral compositions can include at least one mRNA encoding for a TRIM7 protein encapsulated into a lipid nanoparticle (LNP). In other embodiments, methods of making antiviral compositions are disclosed as well as methods of administering a composition having at least one mRNA encoding for a TRIM7 protein encapsulated into LNP into a subject.