专利检索 ap:("THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS") AND inv:"Bradley J. Merrill" 第 1 页

1.

发明公开
CRISPR/CAS SYSTEM AND METHOD FOR GENOME EDITING AND MODULATING TRANSCRIPTION 审中-公开

公开(公告)号：US20240247262A1

公开(公告)日：2024-07-25

申请号：US18464374

申请日：2023-09-11

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： Ryan E. Clarke , Bradley J. Merrill , Matthew S. MacDougall , Hannah M. Pennington , Brian R. Shy

IPC分类号： C12N15/113 , C12N9/22

CPC分类号： C12N15/113 , C12N9/22 , C12Y603/02019 , C07K2319/06 , C07K2319/80 , C07K2319/95 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/20

摘要： A CRISPR/Cas system and method for editing or regulating transcription of a genome of a cell are provided, wherein the system includes a Cas endonuclease fused with one or more degron sequences and at least one activatable cognate single guide RNA harboring an inactivation sequence in a non-essential region of the cognate sgRNA, wherein said inactivation sequence comprises one or more endonuclease recognition sites of, e.g., a ribozyme.

2.

发明申请
CRISPR/CAS SYSTEM AND METHOD FOR GENOME EDITING AND MODULATING TRANSCRIPTION 审中-公开

公开(公告)号：US20200308581A1

公开(公告)日：2020-10-01

申请号：US16650496

申请日：2018-09-21

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： Ryan E. Clarke , Bradley J. Merrill , Matthew S. MacDougall , Hannah M. Pennington , Brian R. Shy

IPC分类号： C12N15/113 , C12N9/22

摘要： A CRISPR/Cas system and method for editing or regulating transcription of a genome of a cell are provided, wherein the system includes a Cas endonuclease fused with one or more degron sequences and at least one activatable cognate single guide RNA harboring an inactivation sequence in a non-essential region of the cognate sgRNA, wherein said inactivation sequence comprises one or more endonuclease recognition sites of, e.g., a ribozyme.

3.

发明授权
CRISPR/Cas system and method for genome editing and modulating transcription 有权

公开(公告)号：US11788088B2

公开(公告)日：2023-10-17

申请号：US16650496

申请日：2018-09-21

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： Ryan E. Clarke , Bradley J. Merrill , Matthew S. MacDougall , Hannah M. Pennington , Brian R. Shy

IPC分类号： C12N15/113 , C12N9/22

CPC分类号： C12N15/113 , C12N9/22 , C12Y603/02019 , C07K2319/06 , C07K2319/80 , C07K2319/95 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/20

摘要： A CRISPR/Cas system and method for editing or regulating transcription of a genome of a cell are provided, wherein the system includes a Cas endonuclease fused with one or more degron sequences and at least one activatable cognate single guide RNA harboring an inactivation sequence in a non-essential region of the cognate sgRNA, wherein said inactivation sequence comprises one or more endonuclease recognition sites of, e.g., a ribozyme.