公开(公告)号：US09629869B2

公开(公告)日：2017-04-25

申请号：US15351512

申请日：2016-11-15

申请人： THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY ,  GUANGZHOU INSTITUTE OF RESPIRATORY DISEASE ,  STATE KEY LABORATORY OF RESPIRATORY DISEASE

发明人： Kefang Lai ,  Shan Zhong ,  Zhenyong Gan ,  Xiaodong Liu ,  Yichu Nie ,  Nanshan Zhong

IPC分类号： A61K36/00 ,  A61K31/715 ,  A61K36/79 ,  A23L29/30 ,  A23P10/00

CPC分类号： A61K31/715 ,  A23L5/00 ,  A23L29/30 ,  A23L33/125 ,  A23P10/00 ,  A23V2002/00 ,  A61K36/79 ,  A61K2236/15 ,  A61K2236/33

摘要： The present invention relates to a new application of Fructus schisandrae total polysaccharides in preparation of medicine or nutraceuticals for treating coughing, and more specifically to a new application of Fructus schisandrae total polysaccharides in preparation of medicine or nutraceuticals for preventing and relieving coughing and eliminating airway inflammation. Experiments demonstrate that the Fructus schisandrae total polysaccharides can remarkably reduce the coughing times of a guinea pig with increased cough sensitivity induced by cigarette smoke and an acute cough guinea pig induced by citric acid smoke, prolong the latent period of cough, and significantly reduce the airway inflammation of the guinea pig with increased cough susceptibility induced by cigarette smoke, so that the Fructus schisandrae total polysaccharides can be used for preparing drugs for preventing cough, relieving cough and eliminating airway inflammation.

公开(公告)号：US10744152B2

公开(公告)日：2020-08-18

申请号：US15996504

申请日：2018-06-03

申请人： THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY ,  GUANGZHOU INSTITUTE OF RESPIRATORY DISEASE

发明人： Kefang Lai ,  Xiaodong Liu ,  Bonian Zhong ,  Shan Zhong ,  Yichu Nie

IPC分类号： A61K36/00 ,  A61K31/715 ,  A61K36/268

摘要： The present invention discloses an Asarum total polysaccharide extract with antitussive activity, an extraction method thereof and an application in the preparation of a medicine for preventing and treating coughs. The present invention proves that the Asarum total polysaccharide extract has a significant effect of suppressing cough for the first time through a large number of pharmacodynamic tests, has the therapeutic effect approximate to codeine, has the effect of prolonging the cough latent period better than codeine, and also finds that the total Asarum polysaccharide extract has the effects of reducing the cough sensitivity and suppressing the airway inflammation for the first time, has excellent preventive and therapeutic effects on various types of coughs, and can be used for preparing the medicines for preventing and treating cough-related diseases.

公开(公告)号：US20170056431A1

公开(公告)日：2017-03-02

申请号：US15351512

申请日：2016-11-15

申请人： THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY ,  GUANGZHOU INSTITUTE OF RESPIRATORY DISEASE ,  STATE KEY LABORATORY OF RESPIRATORY DISEASE

发明人： Kefang Lai ,  Shan Zhong ,  Zhenyong Gan ,  Xiaodong Liu ,  Yichu Nie ,  Nanshan Zhong

IPC分类号： A61K31/715 ,  A23L29/30 ,  A23P10/00 ,  A61K36/79

CPC分类号： A61K31/715 ,  A23L5/00 ,  A23L29/30 ,  A23L33/125 ,  A23P10/00 ,  A23V2002/00 ,  A61K36/79 ,  A61K2236/15 ,  A61K2236/33

摘要： The present invention relates to a new application of Fructus schisandrae total polysaccharides in preparation of medicine or nutraceuticals for treating coughing, and more specifically to a new application of Fructus schisandrae total polysaccharides in preparation of medicine or nutraceuticals for preventing and relieving coughing and eliminating airway inflammation. Experiments demonstrate that the Fructus schisandrae total polysaccharides can remarkably reduce the coughing times of a guinea pig with increased cough sensitivity induced by cigarette smoke and an acute cough guinea pig induced by citric acid smoke, prolong the latent period of cough, and significantly reduce the airway inflammation of the guinea pig with increased cough susceptibility induced by cigarette smoke, so that the Fructus schisandrae total polysaccharides can be used for preparing drugs for preventing cough, relieving cough and eliminating airway inflammation.

摘要翻译： 本发明涉及五味子总多糖在制备用于治疗咳嗽的药物或营养品中的新应用，更具体地涉及五味子总多糖在制备用于预防和减轻咳嗽和消除气道炎症的药物或营养品中的新应用 。 实验表明，五味子总多糖可以显着降低豚鼠咳嗽时间，吸烟引起咳嗽敏感性增加，柠檬酸烟引起急性咳嗽豚鼠，延长咳嗽潜伏期，明显减少气道 香烟烟雾引起的咳嗽易感性增加的豚鼠发炎，使五味子总多糖可用于制备预防咳嗽，缓解咳嗽和消除呼吸道炎症的药物。