公开(公告)号：US20230190663A1

公开(公告)日：2023-06-22

申请号：US17950573

申请日：2022-09-22

申请人： THE GEORGE WASHINGTON UNIVERSITY

发明人： ROHAN FERNANDES ,  PREETHI BALA BALAKRISHNAN ,  CARISSA STOVER ,  ALBERTO BOSQUE ,  INDRA SARABIA ,  ANVITHA SHRI RAMANUJAM

IPC分类号： A61K9/50 ,  A61K45/06 ,  A61P31/18

CPC分类号： A61K9/5073 ,  A61K45/06 ,  A61P31/18 ,  A61K9/5146

摘要： Embodiments of the instant disclosure relate to novel compositions and methods for the treatment of retroviruses (e.g., HIV) and the reduction and/or eradication of latent HIV reservoirs. Compositions herein may include biofunctionalized nanocomposites comprised of a core nanoparticle formed of Prussian blue materials, a shell obtained by partially or completely encapsulating the Prussian blue core with at least one biocompatible coating, and at least one biomolecule attached to, or absorbed to, the biocompatible coating and uses thereof.

公开(公告)号：US20240026294A1

公开(公告)日：2024-01-25

申请号：US18219930

申请日：2023-07-10

申请人： THE GEORGE WASHINGTON UNIVERSITY ,  CHILDREN'S NATIONAL MEDICAL CENTER

发明人： ELIZABETH SWEENEY ,  ROHAN FERNANDES ,  MATTHEW TOVAR ,  PALAK SEKHRI ,  PREETHI BALA BALAKRISHNAN ,  CONRAD RUSSELL CRUZ

IPC分类号： C12N5/0783 ,  A61K45/06 ,  A61K35/17

CPC分类号： C12N5/0638 ,  A61K45/06 ,  A61K35/17 ,  C12N2501/2306 ,  C12N2501/2307 ,  C12N2501/2312 ,  C12N2501/2315 ,  C12N2501/22 ,  C12N2501/25 ,  C12N2501/2301 ,  C12N2501/2304

摘要： The present disclosure generally relates target cancer cell specific immunotherapy compositions, methods of making and use thereof. Also provided in the disclosure are methods of treating a cancer in a subject in need thereof.