公开(公告)号：US20240345376A1

公开(公告)日：2024-10-17

申请号：US18642730

申请日：2024-04-22

申请人： The George Washington University

发明人： Inhee Chung

IPC分类号： G02B21/00

CPC分类号： G02B21/0088 ,  G02B21/0064 ,  G02B21/0068 ,  G02B21/0072

摘要： Systems and methods for microscopic imaging include an inverted microscope directed at a sample on a coverglass, where the sample is comprised of one or more cells and one or more chromophores. A ridge separates the coverglass from a silicon dioxide layer, and a silicon mirror is situated on the silicon dioxide layer, opposite the ridge and coverglass, while a weight is situated against the silicon mirror, opposite the silicon dioxide layer. The inverted microscope uses a spatial light modulator to diffract light through a linear polarizer and a filter wheel comprised of one or more Fourier filters. A beam or beams of s-polarized light is directed to the silicon mirror to create axial light modulation with its reflection on the silicon mirror, producing image data that is captured at a light detector.

公开(公告)号：US20240269473A1

公开(公告)日：2024-08-15

申请号：US18569649

申请日：2022-06-27

申请人： NORTHWESTERN UNIVERSITY ,  THE GEORGE WASHINGTON UNIVERSITY

发明人： John A. Rogers ,  Yeonsik Choi ,  Igor Efimov ,  Rose T. Yin

IPC分类号： A61N1/372 ,  A61L31/02 ,  A61L31/10 ,  A61L31/14 ,  A61N1/02 ,  A61N1/05 ,  A61N1/362 ,  A61N1/375 ,  A61N1/378 ,  A61N1/39

CPC分类号： A61N1/37229 ,  A61L31/10 ,  A61L31/148 ,  A61N1/025 ,  A61N1/059 ,  A61N1/0595 ,  A61N1/362 ,  A61N1/37512 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3787 ,  A61N1/39622 ,  A61L31/022

摘要： A device implantable on a target of interest of a subject for pacemaker, neuromodulator, and/or defibrillator therapy comprises a wireless power harvesting unit configured to deliver power via resonant inductive coupling to the target tissue for stimulation in a manner that eliminates need for batteries and allows for externalized control without transcutaneous leads. The device relies exclusively on materials that resorb when exposed to biofluids in a time-controlled manner via metabolic action and hydrolysis. The materials and design choices create a thin, flexible, and lightweight form that maintain excellent biocompatibility and stable function throughout a desired period of use. Over a subsequent timeframe following the completion of therapy, the devices disappear completely through natural biological processes. These characteristics and a miniaturized geometry facilitate full implantation into the body to eliminate the need for percutaneous hardware, which thereby minimizes the risk of device-associated infections and dislodgement.

公开(公告)号：US20240175007A1

公开(公告)日：2024-05-30

申请号：US18429316

申请日：2024-01-31

申请人： THE GEORGE WASHINGTON UNIVERSITY

发明人： Erik Ali RODRIGUEZ ,  Sara MATTSON ,  Felipe MONTECINOS-FRANJOLA ,  Nicholas CSIKAI ,  Leena ZITOUN

IPC分类号： C12N15/10 ,  C12N9/12 ,  C12N15/86

CPC分类号： C12N15/1058 ,  C12N9/1252 ,  C12N15/86

摘要： Disclosed herein are compositions for and methods of directing evolution of biomolecules. The disclosed methods simplify traditional error prone PCR of a single or multiple genes expressed on plasmid DNA for directed evolution and remove several previously required molecular biology steps, thereby affording facile purification of plasmid DNA expressing biomolecules directly from mammalian cells.

公开(公告)号：US20240117797A1

公开(公告)日：2024-04-11

申请号：US18336425

申请日：2023-06-16

申请人： The George Washington University

发明人： Michael KEIDAR ,  Anmol TAPLOO ,  Li LIN

IPC分类号： F03H1/00 ,  H05H15/00

CPC分类号： F03H1/0037 ,  H05H15/00

摘要： A plasma thruster has a tunable electron source configured to provide electrons with controllable energy. An entry electrode and an exit electrode permit an air flow to pass from the entry electrode to the exit electrode. The entry electrode and exit electrode receive electrons from the tunable electron source. A controller selectively controls the entry and exit electrodes to accelerate positive and negative ions in the air.

公开(公告)号：US20240117292A1

公开(公告)日：2024-04-11

申请号：US18509951

申请日：2023-11-15

申请人： THE GEORGE WASHINGTON UNIVERSITY

发明人： Emilia ENTCHEVA ,  Christianne Joan CHUA

IPC分类号： C12M1/42 ,  C12N5/077

CPC分类号： C12M35/02 ,  C12M35/04 ,  C12M35/06 ,  C12N5/0657 ,  A61N1/362

摘要： Embodiments of the instant disclosure relate to compositions and methods of use thereof that allow for faster integration of acute cardiac pacing experiments compared to the direct genetic modification methods currently in use. Embodiments provided herein provide for spheroids that may be stored, transported, and deployed on site to confer optical pacing of cardiac tissue for use in high-throughput functional in vitro screening assays.

公开(公告)号：US20240047676A1

公开(公告)日：2024-02-08

申请号：US18230547

申请日：2023-08-04

申请人： The George Washington University

发明人： Michael Wagner

IPC分类号： H01M4/583

CPC分类号： H01M4/583 ,  H01M2004/028

摘要： Systems and methods are disclosed for a method of production of carbon nanochain, for use as cathodes, either alone or in combination with multi-walled carbon nanotubes. The carbon nanochain precursors are heated in the presence of inert atmosphere to synthesize the carbon nanochains. The carbon nanochains have high gravimetric and volumetric capacity and good cycle life when used as cathodes in Li—O2 batteries. The performance of Li—O2 battery cathodes comprised of mixtures of carbon nanochains and multiwalled carbon nanotubes is dramatically improved relative to cathodes comprised of either material in the absence of the other.

公开(公告)号：US11861049B2

公开(公告)日：2024-01-02

申请号：US16774826

申请日：2020-01-28

申请人： The George Washington University

发明人： Guru Prasadh V. Venkataramani ,  Milos Doroslovacki ,  Fan Yao ,  Hongyu Fang

IPC分类号： G06F21/75 ,  G06F12/0846 ,  G06F21/55 ,  G06N5/04 ,  G06F17/14

CPC分类号： G06F21/75 ,  G06F12/0848 ,  G06F21/554 ,  G06N5/04 ,  G06F17/141 ,  G06F2212/601 ,  G06F2212/604 ,  G06F2221/033

摘要： A system and method for defense against cache timing channel attacks using cache management hardware is provided. Sensitive information leakage is a growing security concern exacerbated by shared hardware structures in computer processors. Recent studies have shown how adversaries can exploit cache timing channel attacks to exfiltrate secret information. To effectively guard computing systems against such attacks, embodiments disclosed herein provide practical defense techniques that are readily deployable and introduce only minimal performance overhead. In this regard, a new protection framework against cache timing channel attacks is provided herein by leveraging commercial off-the-shelf (COTS) hardware support in processor caches, including last level caches (LLC), for cache monitoring and partitioning. This framework applies signal processing techniques on per-domain cache occupancy data to identify suspicious application contexts. Dynamic way partitioning is then used to disband domains that are involved in timing channels

公开(公告)号：US20230371984A1

公开(公告)日：2023-11-23

申请号：US18319445

申请日：2023-05-17

申请人： Washington University ,  The George Washington University

发明人： Eric Leuthardt ,  Guy Genin ,  Peter Brunner ,  Robert Pless ,  Camilo Molina ,  Carl Hacker ,  Daniel Moran ,  Alicia Repka ,  Halle Lowe ,  Jacob Sandler

IPC分类号： A61B17/58 ,  A61B34/20 ,  A61B90/00

CPC分类号： A61B17/58 ,  A61B34/20 ,  A61B90/39 ,  A61B2034/2055

摘要： Among the various aspects of the present disclosure is the provision of devices, systems, and methods for tracking the positions and orientations of at least one bone screw implanted within a surgical site. The disclosed device includes an extension that includes an extension base configured to couple to the bone screw, a marker arm coupled at one end to the extension base in a hinged arrangement, and an optical marker attached to a free end of the marker arm opposite the hinged attachment. The optical marker includes a pair of lenticular arrays in a coplanar arrangement in which the major axes of the lenticular arrays are mutually perpendicular. Each lenticular array is configured to display different hues at different viewing angles. The disclosed method includes transforming a single image of a surgical site containing at least one bone screw and extension into the global positions of each bone screw based on the pixel positions and hues corresponding to the lenticular arrays of each optical marker.

公开(公告)号：US20230235078A1

公开(公告)日：2023-07-27

申请号：US18176072

申请日：2023-02-28

申请人： The BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  THE GEORGE WASHINGTON UNIVERSITY

发明人： Ningyan ZHANG ,  Zhiqiang AN ,  Hui DENG ,  Xiujie SUN ,  Rong LI

IPC分类号： C07K16/28 ,  C12N15/63 ,  A61P35/00

CPC分类号： C07K16/2896 ,  C12N15/63 ,  A61P35/00 ,  C07K2317/20 ,  C07K2317/565

摘要： The present disclosure relates to antibodies binding to tumor discoidin domain receptor 1 (DDR1) and the uses of the antibodies in detecting and treating cancer.

公开(公告)号：US20230190663A1

公开(公告)日：2023-06-22

申请号：US17950573

申请日：2022-09-22

申请人： THE GEORGE WASHINGTON UNIVERSITY

发明人： ROHAN FERNANDES ,  PREETHI BALA BALAKRISHNAN ,  CARISSA STOVER ,  ALBERTO BOSQUE ,  INDRA SARABIA ,  ANVITHA SHRI RAMANUJAM

IPC分类号： A61K9/50 ,  A61K45/06 ,  A61P31/18

CPC分类号： A61K9/5073 ,  A61K45/06 ,  A61P31/18 ,  A61K9/5146

摘要： Embodiments of the instant disclosure relate to novel compositions and methods for the treatment of retroviruses (e.g., HIV) and the reduction and/or eradication of latent HIV reservoirs. Compositions herein may include biofunctionalized nanocomposites comprised of a core nanoparticle formed of Prussian blue materials, a shell obtained by partially or completely encapsulating the Prussian blue core with at least one biocompatible coating, and at least one biomolecule attached to, or absorbed to, the biocompatible coating and uses thereof.