公开(公告)号：US20220257503A1

公开(公告)日：2022-08-18

申请号：US17595855

申请日：2020-05-29

申请人： THE HONG KONG POLYTECHNIC UNIVERSITY

发明人： Lei SUN ,  Lin SONG ,  Guohao WANG ,  Xuandi HOU

IPC分类号： A61K9/00 ,  A61K45/06 ,  A61K9/50

摘要： The present application provides surface-modified novel targeting GVs (such as PH-GVs), lipid GVs and lipid targeting GVs, preparation methods therefor, and applications thereof in tumor diagnosis, imaging and treatment.

公开(公告)号：US20210154489A1

公开(公告)日：2021-05-27

申请号：US16843674

申请日：2020-04-08

申请人： The Hong Kong Polytechnic University Shenzhen Research Institute

发明人： Puxiang LAI ,  Lei SUN ,  Tianting ZHONG ,  Zhihai QIU

IPC分类号： A61N5/06 ,  A61K48/00

摘要： A method for optogenetics experiments, based on wavefront shaping and including: calculating the transmission matrix between an input end and an output end of the multimode fiber under a fixed shape; implanting the output end into an intracranial space of an experimental subject; and performing wavefront compensation to a light to be input into the input end, according to the spatial position of the optical stimulation and the transmission matrix of the multimode fiber, to form a compensated expanded light, and inputting the compensated expanded light from the input end into the multimode fiber, such that the compensated expanded light, after being transmitted by the multimode fiber to the output end and output from the output end, is capable of focusing at the spatial position of the optical stimulation.

公开(公告)号：US20200069801A1

公开(公告)日：2020-03-05

申请号：US16115656

申请日：2018-08-29

申请人： The Hong Kong Polytechnic University

发明人： Lei SUN ,  Zhihai QIU ,  Jinghui GUO

IPC分类号： A61K41/00 ,  A61N7/00

摘要： There is provided a method of sensitising a eukaryotic cell to ultrasound stimulation, said method comprising increasing the mechano-sensitivity of a transmembrane ion channel of the cell to ultrasound by introducing a plurality of entire exogenous gas vesicles proximal to the surface of the cell.