公开(公告)号：US11969402B2

公开(公告)日：2024-04-30

申请号：US17611752

申请日：2020-05-14

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Luis Garza ,  Dongwon Kim

IPC分类号： A61K31/203 ,  A61K8/36 ,  A61K8/60 ,  A61K31/5585 ,  A61K31/713 ,  A61K38/17 ,  A61P17/02 ,  A61P17/14 ,  A61Q19/08

CPC分类号： A61K31/203 ,  A61K8/361 ,  A61K8/606 ,  A61K31/5585 ,  A61K31/713 ,  A61K38/1729 ,  A61P17/02 ,  A61P17/14 ,  A61Q19/08 ,  A61K2800/91

摘要： The present invention relates to the field of skin rejuvenation. Specifically, the present invention provides compositions and methods for promoting skin rejuvenation using a toll-like receptor 3 (TLR3) agonist and retinoic acid or derivatives thereof. In a specific embodiment, a method for treating wrinkles in a subject comprises the steps of (a) administering to the area of the subject comprising a wrinkle a composition comprising an effective amount of retinoic acid or a derivative thereof; and administering to the area of the subject comprising a wrinkle a composition comprising an effective amount of a TLR3 agonist.

公开(公告)号：US20220233490A1

公开(公告)日：2022-07-28

申请号：US17611752

申请日：2020-05-14

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Luis Garza ,  Dongwon Kim

IPC分类号： A61K31/203 ,  A61Q19/08 ,  A61K8/36 ,  A61K8/60 ,  A61K31/713 ,  A61K31/5585 ,  A61K38/17 ,  A61P17/14 ,  A61P17/02

摘要： The present invention relates to the field of skin rejuvenation. Specifically, the present invention provides compositions and methods for promoting skin rejuvenation using a toll-like receptor 3 (TLR3) agonist and retinoic acid or derivatives thereof. In a specific embodiment, a method for treating wrinkles in a subject comprises the steps of (a) administering to the area of the subject comprising a wrinkle a composition comprising an effective amount of retinoic acid or a derivative thereof; and administering to the area of the subject comprising a wrinkle a composition comprising an effective amount of a TLR3 agonist.