专利检索 ap:("THE JOHNS HOPKINS UNIVERSITY" OR "The Penn State Research Foundation") AND inv:"Damian Brett Van Rossum" 第 1 页

1.

发明授权
Compositions which regulate the epithelial brush border Na+/H+ exchanger NHE3 and their methods of use in gastrointestinal disease 有权

公开(公告)号：US09850292B2

公开(公告)日：2017-12-26

申请号：US14400904

申请日：2013-05-17

申请人： THE JOHNS HOPKINS UNIVERSITY , The Penn State Research Foundation

发明人： Mark Donowitz , Nicholas Constantine Zachos , Damian Brett Van Rossum , Randen Patterson

IPC分类号： C07K14/47 , A61K45/06 , A61K35/741 , A61K38/17 , A61K38/00

CPC分类号： C07K14/4705 , A61K35/741 , A61K38/00 , A61K38/1709 , A61K45/06 , C07K14/47 , A61K2300/00

摘要： A synthetic peptide modeled on the IRCX binding area of NHE3, is a competitive inhibitor of the IRCX and both stimulates basal NHE3 activity and prevents elevated Ca2+ and cAMP inhibition of NHE3. Methods of its preparation and use in the prevention and/or treatment of gastrointestinal disease, such as diarrhea are provided.

2.

发明申请
COMPOSITIONS WHICH REGULATE THE EPITHELIAL BRUSH BORDER Na+/H+ EXCHANGER NHE3 AND THEIR METHODS OF USE IN GASTROINTESTINAL DISEASE 有权
标题翻译：调节上皮血液Na + / H +交换剂NHE3的组合物及其在胃肠疾病中的应用方法

公开(公告)号：US20150139956A1

公开(公告)日：2015-05-21

申请号：US14400904

申请日：2013-05-17

申请人： THE JOHNS HOPKINS UNIVERSITY , THE PENNSYLVANIA STATE UNIVERSITY

发明人： Mark Donowitz , Nicholas Constantine Zachos , Damian Brett Van Rossum , Randen Patterson

IPC分类号： C07K14/47 , A61K45/06 , A61K35/741 , A61K38/17

CPC分类号： C07K14/4705 , A61K35/741 , A61K38/00 , A61K38/1709 , A61K45/06 , C07K14/47 , A61K2300/00

摘要： A synthetic peptide modeled on the IRCX binding area of NHE3, is a competitive inhibitor of the IRCX and both stimulates basal NHE3 activity and prevents elevated Ca2+ and cAMP inhibition of NHE3. Methods of its preparation and use in the prevention and/or treatment of gastrointestinal disease, such as diarrhea are provided.

摘要翻译： 在NHE3的IRCX结合区域上建模的合成肽是IRCX的竞争性抑制剂，并且都刺激基础NHE3活性，并且防止NHE3的升高的Ca2 +和cAMP抑制。提供其制备和用于预防和/或治疗胃肠道疾病如腹泻的方法。