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公开(公告)号：US20030203885A1
公开(公告)日：2003-10-30
申请号：US10441857
申请日：2003-05-19
IPC分类号： A61K031/58
CPC分类号： A61K31/4355 , Y10S435/962 , Y10T436/141111
摘要： The present invention sterol-modified hedgehog polypeptides and functional fragments thereof Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the invention, the method provides a means for affecting cholesterol biosynthesis or transport in a cell comprising contacting a cell with an effective amount of a compound that affects hedgehog, thereby affecting cholesterol biosynthesis or transport. The effect may be inhibition or stimulation of cholesterol biosynthesis or transport.
摘要翻译： 本发明固醇修饰的刺猬蛋白多肽及其功能片段描述了基于对刺猬蛋白的胆固醇修饰的抑制影响刺猬蛋白活性的组合物的方法。 在本发明的一个方面，该方法提供了影响细胞中胆固醇生物合成或转运的方法，包括使细胞与有效量的影响刺猬蛋白的化合物接触，从而影响胆固醇生物合成或转运。 该作用可能是抑制或刺激胆固醇生物合成或运输。
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公开(公告)号：US20020045607A1
公开(公告)日：2002-04-18
申请号：US09954727
申请日：2001-09-11
IPC分类号： A61K031/58
CPC分类号： A61K31/4355 , Y10S435/962 , Y10T436/141111
摘要： The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the invention, the method provides a means for affecting cholesterol biosynthesis or transport in a cell comprising contacting a cell with an effective amount of a compound that affects hedgehog, thereby affecting cholesterol biosynthesis or transport. The effect may be inhibition or stimulation of cholesterol biosynthesis or transport.
摘要翻译： 本发明固醇修饰的刺猬蛋白多肽及其功能片段。 描述了基于对刺猬蛋白胆固醇修饰的抑制影响刺猬蛋白活性的组合物的方法。 在本发明的一个方面，该方法提供了影响细胞中胆固醇生物合成或转运的方法，包括使细胞与有效量的影响刺猬蛋白的化合物接触，从而影响胆固醇生物合成或转运。 该作用可能是抑制或刺激胆固醇生物合成或运输。
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公开(公告)号：US20030207853A1
公开(公告)日：2003-11-06
申请号：US10442435
申请日：2003-05-20
IPC分类号： A61K031/58 , A61K031/00
CPC分类号： A61K31/4355 , Y10S435/962 , Y10T436/141111
摘要： The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the invention, the method provides a means for affecting cholesterol biosynthesis or transport in a cell comprising contacting a cell with an effective amount of a compound that affects hedgehog, thereby affecting cholesterol biosynthesis or transport. The effect may be inhibition or stimulation of cholesterol biosynthesis or transport.
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