公开(公告)号：US12115190B2

公开(公告)日：2024-10-15

申请号：US16975933

申请日：2019-02-27

申请人： THE METHODIST HOSPITAL

发明人： Wenhao Chen ,  Xian Chang Li

IPC分类号： A61K35/17 ,  A61K38/20 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  C07K14/47 ,  C07K16/28 ,  C12N5/0783 ,  C12N15/86

CPC分类号： A61K35/17 ,  A61K38/2013 ,  A61K39/3955 ,  A61K45/06 ,  A61P35/00 ,  C07K14/4702 ,  C07K16/2827 ,  C12N5/0638 ,  C12N15/86 ,  A61K2039/505 ,  C12N2740/10043

摘要： Methods to treat cancer in a subject comprising administering to the subject a therapeutically effective amount of T-cells of the subject having increased IRF4 polypeptide expression compared to a control are disclosed. Also disclosed are methods of increasing tumor reactivity of a T-cell by increasing IRF4 polypeptide expression, and methods to predict the likelihood that a subject having cancer will respond therapeutically to administered T-cells having increased IRF4 polypeptide expression. Also disclosed are compositions comprising a T-cell and a viral vector encoding an IRF4 polypeptide. The compositions are methods are useful for treating numerous cancers in which higher level expression of IRF4 in T-cells would be beneficial. In some embodiments, activated tumor specific T-cells having increased IRF4 expression have greater infiltration in tumors and enhanced local immunological responses.