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公开(公告)号：US20230023802A1
公开(公告)日：2023-01-26
申请号：US17756859
申请日：2020-12-07
IPC分类号： A61K9/00 , A61K31/675 , A61K47/22 , A61K9/08
摘要： The present disclosure provides solid drug formulations, in particular to stabilized formulations of phosphonamidate-containing drugs, as well as methods for loading drug delivery devices with solid formulations.
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公开(公告)号：US20230011398A1
公开(公告)日：2023-01-12
申请号：US17781962
申请日：2020-12-04
发明人： Jin WANG
IPC分类号： A61K31/4196 , A61P31/18
摘要： By a Selective Elimination of Host Cells Capable of Producing HIV (SECH) approach, which includes a combination of latency reversal, blocking of new infections, inhibition of autophagy and induction of apoptosis, host cells harboring productive HIV infections can be cleared from a subject. Disclosed herein are methods for treating or inhibiting HIV in a subject, comprising a) reactivating latent HIV integrated into the genome of a cell infected with HIV in the subject, b) optionally administering to the subject an effective amount of a therapeutic agent to inhibit HIV infection, and c) administering to the subject an effective amount of a therapeutic agent to eliminate or reduce the number of cells containing replication-competent HIV. Kits for treating or inhibiting HIV in a subject are also disclosed.
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公开(公告)号：US11376421B2
公开(公告)日：2022-07-05
申请号：US16762542
申请日：2018-11-09
摘要： Example neurostimulation induced medicine devices and methods of use are described herein. An example endotracheal device can include an elongate tubular member having a proximal end and a distal end, an inflatable cuff arranged between the proximal and distal ends of the elongate tubular member, and an electrode array disposed in proximity to an exterior surface of the inflatable cuff. The inflatable cuff can be configured to expand to contact a subject's tracheal wall. Additionally, the electrode array can include a plurality of flexible electrodes, where a set of the flexible electrodes anatomically align with a region of the subject's tracheal wall for selectively targeting vagus nerve activity.
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公开(公告)号：US20220177912A1
公开(公告)日：2022-06-09
申请号：US17601812
申请日：2020-04-13
发明人： Haifa Shen , Gang Li
IPC分类号： C12N15/85 , A61K35/15 , C07K16/30 , C07K14/705 , A61P35/00
摘要： Embodiments of the present disclosure pertain to modified antigen presenting cells that include a recombinant protein appended onto a surface of the antigen presenting cells. The recombinant protein can include: an ectodomain positioned on the surface; a transmembrane domain with a region embedded in the cell membrane; an antigen presenting cell recruiting domain that directs the cells towards the cancer cells; and an antigen presenting cell activator that activates or licenses the antigen presenting cells. Additional embodiments of the present disclosure pertain to methods of expressing the recombinant proteins on antigen presenting cells and utilizing the modified antigen presenting cells for treating various cancers in various subjects. Further embodiments of the present disclosure pertain to nucleotide-containing carriers for expressing the recombinant proteins of the present disclosure in antigen presenting cells.
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公开(公告)号：US20220168322A1
公开(公告)日：2022-06-02
申请号：US17261536
申请日：2019-07-19
申请人： Board of Regents, The University of Texas System , The Methodist Hospital dba Houston Methodist Hospital
发明人： David John TWEARDY , Ren KONG , Uddalak BHARADWAJ , Moses Makokha KASEMBELI , Stephen T. C. WONG
IPC分类号： A61K31/635 , A61K45/06 , A61K31/122 , A61K31/167 , A61K31/427 , A61K31/496 , A61K31/426 , A61K31/454 , A61P35/00
摘要： In one aspect, the present disclosure provides methods of inhibiting STAT3 in a cell comprising contacting the cell with a compound of the formula: (I) wherein the variables are as defined herein. In another aspect, the present disclosure provides methods of using of the compounds disclosed herein for the treatment of cancer.
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6.发明申请公开(公告)号：US20210052563A1
公开(公告)日：2021-02-25
申请号：US16975257
申请日：2019-02-28
IPC分类号： A61K31/4439 , A61K33/30 , A61K33/38 , A61K31/661 , A61K45/06 , A61K9/00 , A61P17/00
摘要： Embodiments of the disclosure include methods and compositions related to treatment or prevention of cancer therapy-induced tissue inflammation, dermatitis, and/or scarring. In particular embodiments one or more proton pump inhibitors are provided to an individual before, during, and/or after receiving anticancer therapy. In some embodiments one or more proton pump inhibitors are provided to an individual before, during, and/or after having a health conditions, allergies, genetic factors and/or exposure to one or more irritants.
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公开(公告)号：USD895812S1
公开(公告)日：2020-09-08
申请号：US29662750
申请日：2018-09-07
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公开(公告)号：US10722129B2
公开(公告)日：2020-07-28
申请号：US16104750
申请日：2018-08-17
IPC分类号： A61B5/1455 , A61B5/026 , A61B5/00
摘要： Embodiments described herein generally relate to devices, methods and systems for determining blood oxygenation. By applying near infrared radiation of an appropriate wavelength to the tissue and determining the absorbance at a plurality of points where the distance between the source of the near infrared radiation and the detector are known, the oxygenation state of the hemoglobin can be determined based on position in a three dimensional space.
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公开(公告)号：US10420838B2
公开(公告)日：2019-09-24
申请号：US15486183
申请日：2017-04-12
IPC分类号： A61K39/395 , A61P35/00 , A61K31/198 , A61K31/337 , A61K31/4422 , A61K31/277 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/554 , A61K31/675 , A61K39/00 , A61K31/155 , A61K31/223 , A61K33/24
摘要： Disclosed are methods for treating one or more mammalian cancers, and in particular, methods for treating human melanoma, or a head or neck cancer, that employ therapeutically-effective amounts of one or more iNOS pathway-inhibitory compounds, either alone, or in combination with one or more selected antihypertensive agents (including, for example, calcium channel antagonists), alone, or further in combination with one or more conventional chemotherapeutic agents. Also disclosed are pharmaceutical formulations that comprise these compositions, as well as methods for their use in treating refractory, metastatic, and/or relapsed cancers, or, for use in the management or reversal of treatment resistance in one or more such mammalian cancers.
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10.发明授权公开(公告)号：US10398907B2
公开(公告)日：2019-09-03
申请号：US14912004
申请日：2014-08-15
摘要： Apparatus for applying Transcranial Magnetic Stimulation (TMS) to an individual, wherein the apparatus comprises: a head mount for disposition on the head of an individual; and a plurality of magnet assemblies for releasable mounting on the head mount, wherein each of the magnet assemblies comprises a permanent magnet, and at least one of (i) a movement mechanism for moving the permanent magnet and/or (ii) a magnetic shield shutter mechanism, for selectively providing a rapidly changing magnetic field capable of inducing weak electric currents in the brain of an individual so as to modify the natural electrical activity of the brain of the individual; wherein the number of magnet assemblies mounted on the head mount, their individual positioning on the head mount, and their selective provision of a rapidly changing magnetic field is selected so as to allow the spatial, strength and temporal characteristics of the magnetic field to be custom tailored for each individual, whereby to provide individual-specific TMS therapy, to assist in diagnosis or to map out brain function in neuroscience research.
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