公开(公告)号：US20240229147A1

公开(公告)日：2024-07-11

申请号：US18366436

申请日：2023-08-07

申请人： THE PROVOST, FELLOWS, SCHOLARS AND OTHER MEMBERS OF BOARD OF TRINITY COLLEGE DUBLIN ,  UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

发明人： Adrian BRACKEN ,  Fiona LANIGAN ,  William GALLAGHER

IPC分类号： C12Q1/6886 ,  A61K31/519 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  A61K31/519 ,  G01N33/57415 ,  G01N33/57484 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158

摘要： A method for predicting risk of recurrence of cancer in an individual with cancer, the method comprising a step of assaying a cancer sample from the individual for positive expression of at least two genes or proteins encoded by those genes selected from the group consisting of FOXM1, UHRF1, PTTG1, E2F1, MYBL2, HMGB2, ATAD2, E2F8, ZNF367 and TCF19, wherein positive expression of the at least two genes correlates with increased risk of recurrence of cancer compared with an individual who does not exhibit positive expression of the at least two genes or proteins encoded by those genes.

公开(公告)号：US20180148788A1

公开(公告)日：2018-05-31

申请号：US15511890

申请日：2015-09-18

申请人： THE PROVOST, FELLOWS, SCHOLARS AND OTHER MEMBERS OF BOARD OF TRINITY COLLEGE DUBLIN ,  UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

发明人： Adrian BRACKEN ,  Fiona LANIGAN ,  William GALLAGHER

IPC分类号： C12Q1/68 ,  G01N33/574 ,  A61K31/519

摘要： A method for predicting risk of recurrence of cancer in an individual with cancer, the method comprising a step of assaying a cancer sample from the individual for positive expression of at least two genes or proteins encoded by those genes selected from the group consisting of FOXM1, UHRF1, PTTG1, E2F1, MYBL2, HMGB2, ATAD2, E2F8, ZNF367 and TCF19, wherein positive expression of the at least two genes correlates with increased risk of recurrence of cancer compared with an individual who does not exhibit positive expression of the at least two genes or proteins encoded by those genes.

公开(公告)号：US20200157643A1

公开(公告)日：2020-05-21

申请号：US16722041

申请日：2019-12-20

申请人： THE PROVOST, FELLOWS, SCHOLARS AND OTHER MEMBERS OF BOARD OF TRINITY COLLEGE DUBLIN ,  UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

发明人： Adrian BRACKEN ,  Fiona LANIGAN ,  William GALLAGHER

IPC分类号： C12Q1/6886 ,  G01N33/574 ,  A61K31/519

摘要： A method for predicting risk of recurrence of cancer in an individual with cancer, the method comprising a step of assaying a cancer sample from the individual for positive expression of at least two genes or proteins encoded by those genes selected from the group consisting of FOXM1, UHRF1, PTTG1, E2F1, MYBL2, HMGB2, ATAD2, E2F8, ZNF367 and TCF19, wherein positive expression of the at least two genes correlates with increased risk of recurrence of cancer compared with an individual who does not exhibit positive expression of the at least two genes or proteins encoded by those genes.