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公开(公告)号：US11992024B2
公开(公告)日：2024-05-28
申请号：US17846600
申请日：2022-06-22
CPC分类号： A23C9/1512 , A23C9/1422 , A23C9/16 , A23J1/20
摘要： A method of producing a low-lactose milk protein concentrate comprising the steps of providing a starting liquid milk protein concentrate, pre-treating the milk protein concentration by ultra-sonication, and treating the pre-treated milk protein concentration by diafiltration to provide a calcium depleted low-lactose milk protein concentrate. The process of the invention provides a milk protein concentrate with high levels of protein, less than 1% lactose, and a calcium level that is depleted by at least 20% compared with an untreated milk protein concentrate.
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公开(公告)号：US20230257867A1
公开(公告)日：2023-08-17
申请号：US18017160
申请日：2021-07-08
发明人： Rocco LUPOI , James LUNNEY
CPC分类号： C23C14/048 , C23C14/28 , C23C14/5813 , C23C14/228 , C23C14/14 , B05B7/228
摘要： A method of mask-free printing of dry nanoparticles, the method comprising generating a dry nanoparticle stream from a feedstock material in an atmospheric gas flow using a laser ablation system at atmospheric pressure, the dry nanoparticle stream uncontaminated by a fluidic carrier medium, wherein the dry nanoparticles uncontaminated by a fluidic carrier medium are directed to a substrate through a nozzle by the gas flow in a dry state and adhere to the substrate.
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公开(公告)号：US20230026468A1
公开(公告)日：2023-01-26
申请号：US17946166
申请日：2022-09-16
摘要： An adhesive formulation such as a hot melt adhesive or a pressure sensitive adhesive is provided comprising 5 to 98% (by weight) biodegradable substantially non-crystalline mcl-PHA. The mcl-PHA may be cured with a peroxide curing agent. The adhesive formulation may include an additional biodegradable polymer, or a non-biodegradable thermoplastic elastomer. Hot melt adhesives comprising significant amounts of biodegradable mcl-PHA, waxes, and tackifiers are also provided.
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公开(公告)号：US20220126372A1
公开(公告)日：2022-04-28
申请号：US17429838
申请日：2020-02-11
发明人： Rocco LUPOI , Ramesh PADAMATI
摘要： The present invention provides a metal powder-polymer matrix film for use in delivering metal powder to a three-dimensional printing process, the matrix comprising at least one metal powder and a polymer sheet, wherein the metal powder is incorporated within the polymer sheet architecture or on the polymer sheet surface, and wherein the polymer sheet has a thickness that is at least half that of the powder thickness.
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公开(公告)号：US20210292736A1
公开(公告)日：2021-09-23
申请号：US17167366
申请日：2021-02-04
发明人： Joanna McGouran , Neil Taylor
IPC分类号： C12N9/96 , C12N9/10 , C07K14/005 , C12N7/00 , G01N33/535
摘要： A process for labelling a target protein, such as a target enzyme, such as a deubiquitinating enzyme (DUB). The process comprises providing a probe-protein complex comprising a probe and the target protein. The probe comprises a recognition element and a warhead. The target protein comprises a cysteine residue and a recognition site. The recognition element is reversibly bound to the recognition site. A stimulus is applied to induce a radical reaction in the probe-protein complex to covalently bond the warhead to the cysteine residue, thereby labelling the target protein. This invention also resides in probes and probe-protein complexes for use in the process.
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公开(公告)号：US10765084B2
公开(公告)日：2020-09-08
申请号：US15507585
申请日：2015-08-29
申请人： The Provost, Fellows, Scholars and other members of Board of Trinity College Dublin , University College Dublin, National University of Ireland, Dublin
发明人： Brian Murphy , Trevor Hodkinson , Fiona Doohan
摘要： A seed coating composition comprising a mixture of a fungal root endophyte isolated from a root of the plant found in low-nutrient, drought-stressed or multiply-stressed conditions and a carrier medium for application of said composition to a target seed, wherein the endophyte is characterised in having a nuclear ribosomal internal transcribed spacer (nr ITS) with at least a 90% sequence identity to any one of SEQ ID NOs: 3 to 15.
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公开(公告)号：US20240229147A1
公开(公告)日：2024-07-11
申请号：US18366436
申请日：2023-08-07
申请人： THE PROVOST, FELLOWS, SCHOLARS AND OTHER MEMBERS OF BOARD OF TRINITY COLLEGE DUBLIN , UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
发明人： Adrian BRACKEN , Fiona LANIGAN , William GALLAGHER
IPC分类号： C12Q1/6886 , A61K31/519 , G01N33/574
CPC分类号： C12Q1/6886 , A61K31/519 , G01N33/57415 , G01N33/57484 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： A method for predicting risk of recurrence of cancer in an individual with cancer, the method comprising a step of assaying a cancer sample from the individual for positive expression of at least two genes or proteins encoded by those genes selected from the group consisting of FOXM1, UHRF1, PTTG1, E2F1, MYBL2, HMGB2, ATAD2, E2F8, ZNF367 and TCF19, wherein positive expression of the at least two genes correlates with increased risk of recurrence of cancer compared with an individual who does not exhibit positive expression of the at least two genes or proteins encoded by those genes.
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公开(公告)号：US20230001052A1
公开(公告)日：2023-01-05
申请号：US17779783
申请日：2020-11-27
申请人： THE PROVOST, FELLOWS, SCHOLARS AND OTHER MEMBERS OF BOARD OF TRINITY COLLEGE DUBLIN , ROYAL COLLEGE OF SURGEONS IN IRELAND
发明人： Conor BUCKLEY , Leyla ZILIC , Fergal O'BRIEN
IPC分类号： A61L27/36
摘要： A method of producing an acellular peripheral nerve graft comprises the steps of providing a section of peripheral nerve, primary treatment of the section of peripheral nerve comprising freezing and then thawing the section of peripheral nerve, freeze-drying the thawed section of peripheral nerve longitudinally to introduce longitudinal pores into the section of peripheral nerve, and decellularization of the section of peripheral nerve comprising contacting the freeze-dried section of peripheral nerve with detergent and enzymatic decellularization agents to provide the acellular peripheral nerve graft. 9. The acellular peripheral nerve graft typically has an average pore size of at least 40 μm and a DNA content of less than 100 ng/mg.
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公开(公告)号：US11413023B2
公开(公告)日：2022-08-16
申请号：US16961224
申请日：2019-01-10
发明人： Garrett Ryan , Colm McGarvey
摘要： A system for performing a minimally invasive percutaneous procedure comprises a medical device comprising a hydrogel delivery needle (4) with a tip and a hydrogel outlet (6), an injectable, shear-thinning, self-healing viscoelastic hydrogel that exhibits a storage modulus (G′) of at least 600 Pa, and a tan δ (G″/G) from 0.1 to 0.6 in dynamic viscoelasticity measured by a rheometer at 1 Hz and 1% strain rate at 25° C. The system may also comprise a coaxial cannula (2) having a lumen configured for receipt of the hydrogel delivery needle (4), wherein the hydrogel delivery needle comprises an adjustable positioning mechanism (8) configured to limit the advancement depth of the hydrogel delivery needle through the coaxial cannula to a predetermined depth distal to a distal-most end of the coaxial cannula.
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公开(公告)号：US20210068917A1
公开(公告)日：2021-03-11
申请号：US17027561
申请日：2020-09-21
发明人： Garrett Ryan , Colm McGarvey
摘要： A medical device stabilizer 1 having a base plate 2 and a compressible medical device grip 3 in the form of a resilient ball 4 with a guide bore 5 on the base plate 2 which can articulate for gripping and positioning medical devices such as CT-guided needles held in the medical device grip 3.
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