专利检索 ap:("THE REGENTS OF THE UNIVERSITY OF CALFORNIA" OR "PFIZER INC.") AND inv:"Tovo DAVID" 第 1 页

1.

发明申请
ANTIBODIES TO COAGULATION FACTOR XIA AND USES THEREOF 有权

公开(公告)号：US20210403600A1

公开(公告)日：2021-12-30

申请号：US17355530

申请日：2021-06-23

申请人： THE REGENTS OF THE UNIVERSITY OF CALFORNIA , PFIZER INC.

发明人： Thomas MIKITA , Lauren K. ELY , Huilan GAO , Yun KIM , Isaac J. RONDON , Tovo DAVID , Shaun R. COUGHLIN

IPC分类号： C07K16/36

摘要： In one aspect, antibodies, or antigen-binding fragments thereof, that specifically bind to activated Factor XI (FXIa) are provided. Also provided are methods of obtaining such antibodies and nucleic acids encoding the same. In another aspect, compositions and therapeutic prevention of thrombotic diseases, disorders or conditions are provided. In another aspect, anti-idiotype antibodies that bind anti-FXIa antibodies of the disclosure, as well as compositions comprising the anti-idiotype antibodies, methods of obtaining the antibodies and nucleic acids encoding the same, are also provided.

2.

发明申请
REVERSAL AGENTS FOR FXIa INHIBITORS 审中-公开

公开(公告)号：US20180216094A1

公开(公告)日：2018-08-02

申请号：US15746269

申请日：2016-07-22

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , PFIZER INC.

发明人： Thomas MIKITA , Lauren K. ELY , Tovo DAVID , Shaun R. COUGHLIN

IPC分类号： C12N9/64 , C07K7/08

CPC分类号： C12N9/6443 , A61K38/00 , C07K7/08 , C07K2319/02 , C12Y304/21027

摘要： The disclosure provides compositions and methods for counteracting the effects of direct activated Factor XI (FXIa) inhibitors in a subject by administering a variant of FXIa.

3.

发明申请
ANTIBODIES TO COAGULATION FACTOR XIa AND USES THEREOF 审中-公开

公开(公告)号：US20200095334A1

公开(公告)日：2020-03-26

申请号：US15746305

申请日：2016-07-22

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , PFIZER INC.

发明人： Thomas MIKITA , Lauren K. ELY , Huilan GAO , Yun KIM , Isaac J. RONDON , Tovo DAVID , Shaun R. COUGHLIN

IPC分类号： C07K16/36

摘要： In one aspect, antibodies, or antigen-binding fragments thereof, that specifically bind to activated Factor XI (FXIa) are provided. Also provided are methods of obtaining such antibodies and nucleic acids encoding the same. In another aspect, compositions and therapeutic prevention of thrombotic diseases, disorders or conditions are provided. In another aspect, anti-idiotype antibodies that bind anti-FXIa antibodies of the disclosure, as well as compositions comprising the anti-idiotype antibodies, methods of obtaining the antibodies and nucleic acids encoding the same, are also provided.