公开(公告)号：US20230126711A1

公开(公告)日：2023-04-27

申请号：US17914246

申请日：2021-03-25

Applicant: The Regents of the University of California

Inventor： Faranak FATTAHI

IPC: A61K35/30 ,  C12N5/0793 ,  C12N5/0735

Abstract: The present disclosure relates generally to methods of inducing differentiation of pluripotent stem cells into enteric nitrergic neurons, and enteric nitrergic neurons produced by such methods. Also provided are used of such enteric nitrergic neurons for screening potential therapeutic agents suitable for preventing and/or treating enteric nervous system disorders, such as gastroparesis, esophageal achalasia, chronic intestinal pseudo-obstruction, and hypertrophic pyloric stenosis, and applications of such enteric nitrergic neurons in regenerative medicine, such as cell transplantation therapy, for preventing and/or treating enteric nervous system disorders.

公开(公告)号：US20250099508A1

公开(公告)日：2025-03-27

申请号：US18726674

申请日：2023-01-03

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Faranak FATTAHI

IPC: A61K35/30 ,  C12N5/079

Abstract: The present disclosure relates generally to two-dimensional and three-dimensional cultures of cells, the cultures comprising one or a plurality of enteric neurons and/or one or a plurality of enteric glial cells. These cells and cultures can be used for screening compounds for neurologically active compounds, for transplantation into subjects for animal models, and for administration to a subject with a gut motility disorder.

公开(公告)号：US20250090501A1

公开(公告)日：2025-03-20

申请号：US18726547

申请日：2023-01-03

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Faranak FATTAHI ,  Homa MAJD

IPC: A61K31/4174 ,  A61K31/166 ,  A61K31/27 ,  A61K31/451 ,  A61P1/00

Abstract: Compounds, pharmaceutical compositions, kits, and methods for treating gut motility disorders are herein. Examples of gut motility disorders to which the compounds, pharmaceutical compositions, kits, and methods are directed include achalasia, Hirschspmng's disease, an intestinal pseudo-obstruction, gastroesophageal reflux disease (GERD), functional dysphagia, functional dyspepsia, irritable bowel syndrome (IBS), gastroparesis, functional constipations, functional diarrhea, and fecal incontinence. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.