公开(公告)号：US20210161943A1

公开(公告)日：2021-06-03

申请号：US17048473

申请日：2019-04-16

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Antoni RIBAS ,  Gabriel Abril RODRIGUEZ ,  Catherine Grasso ,  Davis Y. TORREJON

IPC: A61K31/7105 ,  A61P35/00 ,  C07K16/28 ,  A61K45/06

Abstract: Disclosed herein are methods of treating cancer in a subject, comprising: administering at least one PAK4 inhibitor to the subject; and in certain embodiments administering at least one immunostimulatory agent to the subject. In some aspects, the immunostimulatory agent can be a checkpoint inhibitor. In certain aspects the checkpoint inhibitor can be an anti-PD1 antibody.