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公开(公告)号：US12268463B2
公开(公告)日：2025-04-08
申请号：US18111499
申请日：2023-02-17
Applicant: The Regents of the University of California
Inventor： Michel M. Maharbiz , Jose M. Carmena , Dongjin Seo , Monica Lin , Meir Marmor , Safa Herfat , Chelsea Shields Bahney
IPC: A61B8/08 , A61B5/00 , A61B5/07 , A61B5/279 , A61B6/42 , A61B8/00 , A61N1/36 , A61N1/372 , A61N1/378 , B06B1/06 , G01N27/327 , A61M39/02 , A61N1/05 , A61N5/10 , A61N7/00
Abstract: Described herein is an implantable device configured to detect impedance characteristic of a tissue. In certain exemplary devices, the implantable device comprises (a) an ultrasonic transducer configured to emit an ultrasonic backscatter encoding information relating to an impedance characteristic of a tissue based on a modulated current flowing through the ultrasonic transducer; (b) an integrated circuit comprising (i) a variable frequency power supply electrically connected to a first electrode and a second electrode; (ii) a signal detector configured to detect an impedance, voltage, or current in a circuit comprising the variable frequency power supply, the first electrode, the second electrode, and the tissue; and (iii) a modulation circuit configured to modulate the current flowing through the ultrasonic transducer based on the detected impedance, voltage, or current; and the first electrode and the second electrode configured to be implanted into the tissue in electrical connection with each other through the tissue. Further described are systems including one or more implantable devices and an interrogator for operating the implantable device, methods of measuring impedance characteristic of a tissue in a subject, and methods of monitoring or characterizing a tissue in a subject.
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Patent Agency Ranking
公开(公告)号：US20230277057A1
公开(公告)日：2023-09-07
申请号：US18111499
申请日：2023-02-17
Applicant: The Regents of the University of California
Inventor： Michel M. Maharbiz , Jose M. Carmena , Dongjin Seo , Monica Lin , Meir Marmor , Safa Herfat , Chelsea Shields Bahney
IPC: A61B5/00 , A61B6/00 , A61N1/378 , A61B8/08 , A61B5/07 , A61N1/36 , A61N1/372 , A61B5/279 , B06B1/06 , G01N27/327
CPC classification number: A61B5/0031 , A61B6/4258 , A61N1/3787 , A61B8/0875 , A61B8/48 , A61B5/076 , A61N1/3605 , A61N1/37205 , A61B5/686 , A61B5/279 , A61B8/085 , A61B8/0808 , B06B1/06 , G01N27/327 , A61M39/0208
Abstract: Described herein is an implantable device configured to detect impedance characteristic of a tissue. In certain exemplary devices, the implantable device comprises (a) an ultrasonic transducer configured to emit an ultrasonic backscatter encoding information relating to an impedance characteristic of a tissue based on a modulated current flowing through the ultrasonic transducer; (b) an integrated circuit comprising (i) a variable frequency power supply electrically connected to a first electrode and a second electrode; (ii) a signal detector configured to detect an impedance, voltage, or current in a circuit comprising the variable frequency power supply, the first electrode, the second electrode, and the tissue; and (iii) a modulation circuit configured to modulate the current flowing through the ultrasonic transducer based on the detected impedance, voltage, or current; and the first electrode and the second electrode configured to be implanted into the tissue in electrical connection with each other through the tissue. Further described are systems including one or more implantable devices and an interrogator for operating the implantable device, methods of measuring impedance characteristic of a tissue in a subject, and methods of monitoring or characterizing a tissue in a subject.
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公开(公告)号：US20190150882A1
公开(公告)日：2019-05-23
申请号：US16313860
申请日：2017-07-07
Applicant: The Regents of the University of California
Inventor： Michel M. Maharbiz , Jose M. Carmena , Dongjin Seo , Monica Lin , Meir Marmor , Safa Herfat , Chelsea Bahney
Abstract: Described herein is an implantable device configured to detect impedance characteristic of a tissue. In certain exemplary devices, the implantable device comprises (a) an ultrasonic transducer configured to emit an ultrasonic backscatter encoding information relating to an impedance characteristic of a tissue based on a modulated current flowing through the ultrasonic transducer; (b) an integrated circuit comprising (i) a variable frequency power supply electrically connected to a first electrode and a second electrode; (ii) a signal detector configured to detect an impedance, voltage, or current in a circuit comprising the variable frequency power supply, the first electrode, the second electrode, and the tissue; and (iii) a modulation circuit configured to modulate the current flowing through the ultrasonic transducer based on the detected impedance, voltage, or current; and the first electrode and the second electrode configured to be implanted into the tissue in electrical connection with each other through the tissue. Further described are systems including one or more implantable devices and an interrogator for operating the implantable device, methods of measuring impedance characteristic of a tissue in a subject, and methods of monitoring or characterizing a tissue in a subject.
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公开(公告)号：US20170156658A1
公开(公告)日：2017-06-08
申请号：US15379220
申请日：2016-12-14
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Michel Maharbiz , Vivek Subramanian , Ana Claudia Arias , Sarah Swisher , Amy Liao , Monica Lin , Felippe Pavinatto , Yasser Khan , Daniel Cohen , Elisabeth Leeflang , Shuvo Roy , Michael Harrison , David Young
Abstract: Methods and apparatus for real-time, quantifiable monitoring of high-risk areas of biological tissue are described. The methods and apparatus use impedance spectroscopy to detect subtle changes in tissue health.
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公开(公告)号：US11607128B2
公开(公告)日：2023-03-21
申请号：US16313860
申请日：2017-07-07
Applicant: The Regents of the University of California
Inventor： Michel M. Maharbiz , Jose M. Carmena , Dongjin Seo , Monica Lin , Meir Marmor , Safa Herfat , Chelsea Shields Bahney
IPC: A61B8/08 , A61B5/00 , A61B6/00 , A61N1/378 , A61B5/07 , A61N1/36 , A61N1/372 , A61B5/279 , B06B1/06 , G01N27/327 , A61M39/02 , A61N1/05 , A61N5/10 , A61N7/00
Abstract: Described herein is an implantable device configured to detect impedance characteristic of a tissue. In certain exemplary devices, the implantable device comprises (a) an ultrasonic transducer configured to emit an ultrasonic backscatter encoding information relating to an impedance characteristic of a tissue based on a modulated current flowing through the ultrasonic transducer; (b) an integrated circuit comprising (i) a variable frequency power supply electrically connected to a first electrode and a second electrode; (ii) a signal detector configured to detect an impedance, voltage, or current in a circuit comprising the variable frequency power supply, the first electrode, the second electrode, and the tissue; and (iii) a modulation circuit configured to modulate the current flowing through the ultrasonic transducer based on the detected impedance, voltage, or current; and the first electrode and the second electrode configured to be implanted into the tissue in electrical connection with each other through the tissue. Further described are systems including one or more implantable devices and an interrogator for operating the implantable device, methods of measuring impedance characteristic of a tissue in a subject, and methods of monitoring or characterizing a tissue in a subject.
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公开(公告)号：US10463293B2
公开(公告)日：2019-11-05
申请号：US15379220
申请日：2016-12-14
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Michel Maharbiz , Vivek Subramanian , Ana Claudia Arias , Sarah Swisher , Amy Liao , Monica Lin , Felippe Pavinatto , Yasser Khan , Daniel Cohen , Elisabeth Leeflang , Shuvo Roy , Michael Harrison , David Young
Abstract: Methods and apparatus for real-time, quantifiable monitoring of high-risk areas of biological tissue are described. The methods and apparatus use impedance spectroscopy to detect subtle changes in tissue health.
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