公开(公告)号：US20240417609A1

公开(公告)日：2024-12-19

申请号：US18814146

申请日：2024-08-23

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： PHILLIP MESSERSMITH ,  Subhajit Pal ,  Kelsey G. Defrates ,  Jisoo Shin

IPC: C09J181/04 ,  A61L24/04 ,  C08G75/14 ,  C08G75/26

Abstract: Adhesive compositions for medical and non-medical uses are provided. The adhesive compositions can include cyclic disulfide monomers, oligomers of reactions between the cyclic disulfides, polymers of the cyclic disulfides, solid articles formed formed from the polymers, and any combination thereof. Methods of making, using, and recycling the adhesive compositions are provided, including use of the adhesive compositions on a variety of substrates that include biological tissue; biomaterials, including synthetics and natural such as bone, wood, and cellulosics; metals and alloys; polymers, plastics, and rubbers; ceramics; composites; and, any combination of these materials. The adhesives can adhere to substrates in a variety of environmental conditions that include ambient atmospheric conditions, wet conditions that include adhering materials underwater, and in a wide variety of temperatures and pressures, such as those temperatures and pressures found in medical environments, including in living tissue, as well as many residential, commercial, industrial, and manufacturing environments.

公开(公告)号：US12269925B1

公开(公告)日：2025-04-08

申请号：US18803077

申请日：2024-08-13

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Phillip B. Messersmith ,  Subhajit Pal

IPC: C08G75/14 ,  C08K5/45 ,  C09J181/04

Abstract: Biocompatible and biodegradable polymers are provided herein as compositions, methods, and systems for making the compositions. These polymers can be adjustably stable and used in medical applications as adhesives and sealants, and in non-medical applications. Radical polymerization protocols, and two-step cationic and radical polymerization protocols, are provided for the creation of stable, polydisulfide polymers, which can be done in aqueous solution and at ambient and in vivo temperatures ranging, for example, from 0° C. to 37° C. The compositions are biocompatible and can be used as fast curing, biocompatible and biodegradable adhesives and sealants suitable for use in the consumer, industrial, military and medical arts, namely as a functional biomaterial, sustainable plastic, surgical superglue, bone adhesive, pressure-sensitive adhesive, structural adhesive, and other relevant sustainable materials with closed-loop recycling.

公开(公告)号：US12209206B2

公开(公告)日：2025-01-28

申请号：US18814146

申请日：2024-08-23

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Phillip B. Messersmith ,  Subhajit Pal ,  Kelsey G. Defrates ,  Jisoo Shin

IPC: C09J181/04 ,  A61L24/04 ,  C08G75/14 ,  C08G75/26

Abstract: Adhesive compositions for medical and non-medical uses are provided. The adhesive compositions can include cyclic disulfide monomers, oligomers of reactions between the cyclic disulfides, polymers of the cyclic disulfides, solid articles formed formed from the polymers, and any combination thereof. Methods of making, using, and recycling the adhesive compositions are provided, including use of the adhesive compositions on a variety of substrates that include biological tissue; biomaterials, including synthetics and natural such as bone, wood, and cellulosics; metals and alloys; polymers, plastics, and rubbers; ceramics; composites; and, any combination of these materials. The adhesives can adhere to substrates in a variety of environmental conditions that include ambient atmospheric conditions, wet conditions that include adhering materials underwater, and in a wide variety of temperatures and pressures, such as those temperatures and pressures found in medical environments, including in living tissue, as well as many residential, commercial, industrial, and manufacturing environments.

公开(公告)号：US12152174B2

公开(公告)日：2024-11-26

申请号：US18635583

申请日：2024-04-15

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Phillip B. Messersmith ,  Subhajit Pal ,  Kelsey G. Defrates ,  Jisoo Shin

IPC: C09J181/04 ,  A61L24/04 ,  C08G75/14 ,  C08G75/26

Abstract: Adhesive compositions for medical and non-medical uses are provided. The adhesive compositions can include cyclic disulfide monomers, oligomers of reactions between the cyclic disulfides, polymers of the cyclic disulfides, solid articles formed formed from the polymers, and any combination thereof. Methods of making, using, and recycling the adhesive compositions are provided, including use of the adhesive compositions on a variety of substrates that include biological tissue; biomaterials, including synthetics and natural such as bone, wood, and cellulosics; metals and alloys; polymers, plastics, and rubbers; ceramics; composites; and, any combination of these materials. The adhesives can adhere to substrates in a variety of environmental conditions that include ambient atmospheric conditions, wet conditions that include adhering materials underwater, and in a wide variety of temperatures and pressures, such as those temperatures and pressures found in medical environments, including in living tissue, as well as many residential, commercial, industrial, and manufacturing environments.