公开(公告)号：US20230049954A1

公开(公告)日：2023-02-16

申请号：US17640281

申请日：2020-09-04

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Cristina PUIG-SAUS ,  Antoni RIBAS ,  Yvonne CHEN

IPC: A61K35/17 ,  C07K14/705 ,  C07K14/725 ,  A61P35/00 ,  C07K16/28 ,  A61P17/00

Abstract: Methods and compositions are provided related to therapeutic receptors, including chimeric antigen receptors (CARs), capable of specifically binding TYRP-1. The disclosed compositions include, for example, cells (e.g., immune cells) expressing TYRP-1 specific CARs, nucleic acids encoding TYRP-1 specific CARs, and TYRP-1 specific CAR polypeptides. Certain aspects relate to methods of treating cancer, including melanoma, using compositions comprising TYRP-1 specific CARs, for example cells expressing TYRP-1 specific CARs. In some embodiments, provided herein are chimeric polypeptides comprising a TYRP-1 binding domain, a hinge region, a transmembrane domain, and an intracellular signaling domain.