公开(公告)号：US20220380368A1

公开(公告)日：2022-12-01

申请号：US17760786

申请日：2020-09-18

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Shaomeng Wang ,  Xin Han ,  Weiguo Xiang ,  Bukeyan Miao ,  Chong Qin ,  Lijie Zhao ,  Jianfeng Lu ,  Tianfeng Xu ,  Chao-Yie Yang

IPC: C07D471/10 ,  A61P35/00 ,  A61P13/08

Abstract: The present disclosure provides compounds represented by Formula (I) and the salts or solvates thereof, wherein R3a, E, L, A1, B1, X1, X2, Z1, and Z2 are as defined in the specification. Compounds having Formula (I) are androgen receptor degraders useful for the treatment of cancer and other diseases.

公开(公告)号：US20220079931A1

公开(公告)日：2022-03-17

申请号：US17420417

申请日：2019-12-19

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Shaomeng Wang ,  Jiantao Hu ,  Biao Hu ,  Mingliang Wang ,  Fuming Xu ,  Bukeyan Miao

IPC: A61K31/454 ,  A61K31/381 ,  A61K47/54 ,  A61K31/427 ,  A61K31/40 ,  A61P35/00 ,  A61K31/337 ,  A61K31/566 ,  A61K31/7068 ,  A61K31/704 ,  A61K31/513 ,  A61K31/475 ,  A61K31/138 ,  A61K31/519 ,  A61K31/565

Abstract: The present disclosure provides compounds represented by Formula (I): A-L-B and the salts or solvates thereof, wherein A, L, and B are as defined in the specification. Compounds having Formula I are estrogen receptor degraders useful for the treatment of cancer.