公开(公告)号：US11220479B2

公开(公告)日：2022-01-11

申请号：US17076852

申请日：2020-10-22

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Scott D. Larsen ,  James A. Shayman ,  Kim Hutchings ,  Neil Moss ,  Qin Jiang ,  Nicholas Mayhew ,  Emily Freeman ,  Zohreh Sajjadi Hashemi

IPC: C07D205/04 ,  C07D207/09 ,  C07D405/12

Abstract: Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.

公开(公告)号：US20210122712A1

公开(公告)日：2021-04-29

申请号：US17076852

申请日：2020-10-22

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Scott D. Larsen ,  James A. Shayman ,  Kim Hutchings ,  Neil Moss ,  Qin Jiang ,  Nicholas Mayhew ,  Emily Freeman ,  Zohreh Saijadi Hashemi

IPC: C07D205/04 ,  C07D207/09 ,  C07D405/12

Abstract: Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.