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公开(公告)号:US20210122712A1
公开(公告)日:2021-04-29
申请号:US17076852
申请日:2020-10-22
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor: Scott D. Larsen , James A. Shayman , Kim Hutchings , Neil Moss , Qin Jiang , Nicholas Mayhew , Emily Freeman , Zohreh Saijadi Hashemi
IPC: C07D205/04 , C07D207/09 , C07D405/12
Abstract: Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.
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公开(公告)号:US11220479B2
公开(公告)日:2022-01-11
申请号:US17076852
申请日:2020-10-22
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor: Scott D. Larsen , James A. Shayman , Kim Hutchings , Neil Moss , Qin Jiang , Nicholas Mayhew , Emily Freeman , Zohreh Sajjadi Hashemi
IPC: C07D205/04 , C07D207/09 , C07D405/12
Abstract: Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.
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3.
公开(公告)号:US20230212123A1
公开(公告)日:2023-07-06
申请号:US17920794
申请日:2021-04-20
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor: Scott D. Larsen , James A. Shayman , Michael William Wilson , Neil Moss
IPC: C07D213/64 , C07D213/65 , C07D213/40 , C07D213/68 , C07D401/06 , C07D213/61 , A61K45/06
CPC classification number: C07D213/64 , A61K45/06 , C07D213/40 , C07D213/61 , C07D213/65 , C07D213/68 , C07D401/06
Abstract: Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.
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