公开(公告)号：US20240226104A1

公开(公告)日：2024-07-11

申请号：US18556250

申请日：2022-04-20

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Wei Gao ,  Duxin Sun ,  Fei Wen ,  Ruiting Li ,  Hongxiang Hu ,  Luke F. Bugada ,  Yudong Song ,  Mahamadou Djibo

IPC: A61K31/519 ,  A61K9/00 ,  A61K9/51 ,  A61K31/337 ,  A61P35/04

CPC classification number: A61K31/519 ,  A61K9/0019 ,  A61K9/5169 ,  A61K31/337 ,  A61P35/04

Abstract: The present disclosure provides phosphatidylinositol 3-kinase (PI3K) inhibitors, and compositions, nanoformulations and methods for treating diseases or disorders (e.g., breast cancer, pancreatic cancer, lung cancer, and lymphoma) with PBK inhibitors or composition thereof. Disclosed herein is a composition comprising: an effective amount of a PI3K inhibitor or a pharmaceutically acceptable salt thereof; and an albumin nanoparticle.