公开(公告)号：US11819516B2

公开(公告)日：2023-11-21

申请号：US15773952

申请日：2016-11-04

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Fei Wen ,  Mason Smith

IPC分类号： C12N15/62 ,  C12N5/0783 ,  C07K14/39 ,  A61K35/17 ,  A61K48/00 ,  A61K47/61 ,  A61K47/68 ,  A61K38/17 ,  C07K19/00

CPC分类号： A61K35/17 ,  A61K38/1774 ,  A61K47/61 ,  A61K47/6889 ,  A61K48/00 ,  C07K14/39 ,  C07K19/00 ,  C12N5/0636 ,  C12N15/62 ,  C07K2318/10 ,  C07K2319/02 ,  C07K2319/035

摘要： Provided herein is technology relating to immunotherapy and particularly, but not exclusively, to compositions, methods, and kits for immunotherapy and activation of T cells using a peptide-major histocompatibility complex (pMHC) assembled on a protein scaffold for patterned signal presentation of T cell activating ligands to T cells.