公开(公告)号：US20190262453A1

公开(公告)日：2019-08-29

申请号：US16344262

申请日：2017-10-24

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

Inventor： Gustavo Rosania ,  Paul J.A. Kenis ,  Tehetina Woldemichael ,  Mikhail M. Murashov ,  Phillip Rzeczycki ,  Rahul K. Keswani ,  Elizabeth M. Horstman

IPC: A61K47/02 ,  A61K9/107 ,  A61K31/498 ,  A61K9/127 ,  A61P29/00

Abstract: Provided herein are physiologically insoluble insoluble forms of drugs. In particular, provided herein are physiologically insoluble insoluble salts of drugs (e.g., basic drugs) and their use in treatment of disease.

公开(公告)号：US20160220710A1

公开(公告)日：2016-08-04

申请号：US15011047

申请日：2016-01-29

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Rahul K. Keswani ,  Gi S. Yoon ,  Kathleen Stringer ,  Gustavo Rosania ,  Chao Tian ,  Xueding Wang

IPC: A61K49/22 ,  A61K31/498 ,  A61K9/127

CPC classification number: A61K31/498 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0078 ,  A61K9/127 ,  A61K49/0067 ,  A61K49/225 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/411

Abstract: Provided herein are microcrystalline forms of drugs. In particular, provided herein are microcrystalline drug formulations for delivery to macrophages and treatment of disease.

Abstract translation: 本文提供的是微晶形式的药物。 特别地，本文提供了用于递送至巨噬细胞的微晶药物制剂和疾病的治疗。