-
1.发明申请公开(公告)号：US20250001211A1
公开(公告)日：2025-01-02
申请号：US18883578
申请日：2024-09-12
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor： Issam El Naqa , Xueding Wang , Paul Carson , Kyle Cuneo , Jean Moran , Wei Zhang , Ibrahim Oraiqat
Abstract: A method and system for performing online adapted radiotherapy are provided using combined ultrasound and ionizing radiation induced acoustic imaging (iRAI) computed tomography imaging techniques that can be used for measurement of low to ultrahigh dose deliveries (>40 Gy/s). Multiplexed transducers detect US and iRAI signals allowing for anatomical/functional imaging and radiation mapping with absolute dosimetry measurements of a region of interest during a radiotherapy session. Corrections to radiation dosage intensities and locations is determined and provided as feedback to a radiation source to improve the accuracy of applied radiation dosages intra- or inter-radiotherapy treatment sessions preventing the irradiation of healthy tissues and ensuring the accurate delivery of radiation to a tumor or region of interest.
-
2.发明授权公开(公告)号：US12102843B2
公开(公告)日：2024-10-01
申请号：US17600564
申请日：2020-05-11
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor： Issam El Naqa , Xueding Wang , Paul Carson , Kyle Cuneo , Jean Moran , Wei Zhang , Ibrahim Oraiqat
CPC classification number: A61N5/1067 , A61B8/08 , A61B8/485 , A61N5/1038 , A61N5/1039 , A61N5/1049 , A61N5/1071 , A61N2005/1054 , A61N2005/1058
Abstract: A method and system for performing online adapted radiotherapy are provided using combined ultrasound and ionizing radiation induced acoustic imaging (iRAI) computed tomography imaging techniques that can be used for measurement of low to ultrahigh dose deliveries (>40 Gy/s). Multiplexed transducers detect US and iRAI signals allowing for anatomical/functional imaging and radiation mapping with absolute dosimetry measurements of a region of interest during a radiotherapy session. Corrections to radiation dosage intensities and locations is determined and provided as feedback to a radiation source to improve the accuracy of applied radiation dosages intra- or inter-radiotherapy treatment sessions preventing the irradiation of healthy tissues and ensuring the accurate delivery of radiation to a tumor or region of interest.
-
公开(公告)号：US11511138B2
公开(公告)日：2022-11-29
申请号：US15584317
申请日：2017-05-02
Inventor： Xinmai Yang , Xueding Wang , Yannis M. Paulus
Abstract: A method of removing microvessels includes applying a burst of acoustic energy at a target location, applying a pulse of optical energy at the target location, and promoting cavitation at the target location. The burst of acoustic energy has a pressure below 5.0 MPa. The pulse of optical energy at the target location has a fluence less than 100 mJ/cm2. At least a portion of the pulse is concurrent with the burst and the optical energy has an optical area that is overlapping with an acoustic area of the acoustic energy at the target location.
-
公开(公告)号：US10746706B2
公开(公告)日：2020-08-18
申请号：US15108717
申请日：2015-01-05
Applicant: The Regents of the University of Michigan
Inventor： Xueding Wang , Cheri Deng , Paul L. Carson , Guan Xu
Abstract: A method of performing a photoacoustic physio-chemical analysis is provided. The method includes performing one or more photoacoustic scans on a tissue to generate a plurality of photoacoustic signals. The photoacoustic signals are transformed into a frequency domain to form a power spectra. The method also includes generating a two dimensional (2D) physio-chemical spectrogram from the power spectra. A probe for performing a photoacoustic physio-chemical analysis is also provided.
-
5.发明申请公开(公告)号：US20220212036A1
公开(公告)日：2022-07-07
申请号：US17600564
申请日：2020-05-11
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor： Issam El Naqa , Xueding Wang , Paul Carson , Kyle Cuneo , Jean Moran , Wei Zhang , Ibrahim Oraiqat
Abstract: A method and system for performing online adapted radiotherapy are provided using combined ultrasound and ionizing radiation induced acoustic imaging (iRAI) computed tomography imaging techniques that can be used for measurement of low to ultrahigh dose deliveries (>40 Gy/s). Multiplexed transducers detect US and iRAI signals allowing for anatomical/functional imaging and radiation mapping with absolute dosimetry measurements of a region of interest during a radiotherapy session. Corrections to radiation dosage intensities and locations is determined and provided as feedback to a radiation source to improve the accuracy of applied radiation dosages intra- or inter-radiotherapy treatment sessions preventing the irradiation of healthy tissues and ensuring the accurate delivery of radiation to a tumor or region of interest.
-
Patent Agency Ranking
公开(公告)号：US20170312552A1
公开(公告)日：2017-11-02
申请号：US15584317
申请日：2017-05-02
Inventor： Xinmai Yang , Xueding Wang , Yannis M. Paulus
CPC classification number: A61N7/022 , A61B5/103 , A61B5/1079 , A61F9/008 , A61N2007/0095
Abstract: A method of removing microvessels includes applying a burst of acoustic energy at a target location, applying a pulse of optical energy at the target location, and promoting cavitation at the target location. The burst of acoustic energy has a pressure below 5.0 MPa. The pulse of optical energy at the target location has a fluence less than 100 mJ/cm2. At least a portion of the pulse is concurrent with the burst and the optical energy has an optical area that is overlapping with an acoustic area of the acoustic energy at the target location.
-
公开(公告)号：US20210353142A1
公开(公告)日：2021-11-18
申请号：US17320755
申请日：2021-05-14
Applicant: The Regents of the University of Michigan
Inventor： Wei Zhang , Xueding Wang , Yannis Paulus
Abstract: The present invention relates to systems for low-energy (e.g., 1.0 nJ-7.0 nJ) photoacoustic microscopy and methods for employing such systems. In certain embodiments, such systems employ a low-energy nanosecond pulsed laser beam (NPLB), at least two amplifiers, and a data acquisition system with at least three channels to generate at least three digital signals (e.g., which are averaged and normalized to the energy of the NPLB). In other embodiments, provided herein are systems for combined use of photoacoustic microscopy, dye-based microscopy (e.g., with fluorescein), and optical coherence tomography.
-
公开(公告)号：US20160220710A1
公开(公告)日：2016-08-04
申请号：US15011047
申请日：2016-01-29
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor： Rahul K. Keswani , Gi S. Yoon , Kathleen Stringer , Gustavo Rosania , Chao Tian , Xueding Wang
IPC: A61K49/22 , A61K31/498 , A61K9/127
CPC classification number: A61K31/498 , A61K9/0019 , A61K9/0043 , A61K9/0078 , A61K9/127 , A61K49/0067 , A61K49/225 , Y02A50/385 , Y02A50/401 , Y02A50/411
Abstract: Provided herein are microcrystalline forms of drugs. In particular, provided herein are microcrystalline drug formulations for delivery to macrophages and treatment of disease.
Abstract translation: 本文提供的是微晶形式的药物。 特别地，本文提供了用于递送至巨噬细胞的微晶药物制剂和疾病的治疗。
-
公开(公告)号：US12029490B2
公开(公告)日：2024-07-09
申请号：US17320755
申请日：2021-05-14
Applicant: The Regents of the University of Michigan
Inventor： Wei Zhang , Xueding Wang , Yannis Paulus
CPC classification number: A61B3/13 , A61B3/102 , A61B5/0095 , G02B27/141
Abstract: The present invention relates to systems for low-energy (e.g., 1.0 nJ-7.0 nJ) photoacoustic microscopy and methods for employing such systems. In certain embodiments, such systems employ a low-energy nanosecond pulsed laser beam (NPLB), at least two amplifiers, and a data acquisition system with at least three channels to generate at least three digital signals (e.g., which are averaged and normalized to the energy of the NPLB). In other embodiments, provided herein are systems for combined use of photoacoustic microscopy, dye-based microscopy (e.g., with fluorescein), and optical coherence tomography.
-
公开(公告)号：US12000782B2
公开(公告)日：2024-06-04
申请号：US17421809
申请日：2020-01-09
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor： Xudong Fan , Xueding Wang , Xuzhou Li , Yu Qin , Xiaotian Tan , Yu-Cheng Chen , Qiushu Chen
CPC classification number: G01N21/63 , A61B5/6876 , H01S3/08059 , H01S3/083 , H01S3/094076 , G01N2201/06113
Abstract: A laser whose emission is modulated by ultrasound is presented. The laser is usually micron-sized. In response to ultrasound modulation, the laser emission increases and decreases. Such a change in emission can be detected by external optical detectors. This type of laser can be used as a new type of imaging modality, in which laser emission in combination with sound waves or ultrasound waves, is used for imaging Laser emission has a much narrower spectral linewidth and stronger intensity than fluorescence and therefore is able to achieve higher sensitivity, whereas sound waves are used to provide a better spatial resolution of the laser emission from the laser. In ultrasound modulated laser based imaging, multiple lasers can be placed inside cells or tissues.
-
-
-
-
-
-
-
-
-
Search Results
11
records
(took 0.02 seconds)
