公开(公告)号：US20220099573A1

公开(公告)日：2022-03-31

申请号：US17421809

申请日：2020-01-09

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Xudong FAN ,  Xueding WANG ,  Xuzhou LI ,  Yu QIN ,  Xiaotian TAN ,  Yu-Cheng CHEN ,  Qiushu CHEN

IPC分类号： G01N21/63 ,  H01S3/08 ,  A61B5/00 ,  H01S3/083 ,  H01S3/094

摘要： A laser whose emission is modulated by ultrasound is presented. The laser is usually micron-sized. In response to ultra-sound modulation, the laser emission increases and decreases. Such a change in emission can be detected by external optical detectors. This type of laser can be used as a new type of imaging modality, in which laser emission in combination with sound waves or ultra-sound waves, is used for imaging Laser emission has a much narrower spectral linewidth and stronger intensity than fluorescence and therefore is able to achieve higher sensitivity, whereas sound waves are used to provide a better spatial resolution of the laser emission from the laser. In ultrasound modulated laser based imaging, multiple lasers can be placed inside cells or tissues.