公开(公告)号：US20220099573A1

公开(公告)日：2022-03-31

申请号：US17421809

申请日：2020-01-09

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Xudong FAN ,  Xueding WANG ,  Xuzhou LI ,  Yu QIN ,  Xiaotian TAN ,  Yu-Cheng CHEN ,  Qiushu CHEN

IPC分类号： G01N21/63 ,  H01S3/08 ,  A61B5/00 ,  H01S3/083 ,  H01S3/094

摘要： A laser whose emission is modulated by ultrasound is presented. The laser is usually micron-sized. In response to ultra-sound modulation, the laser emission increases and decreases. Such a change in emission can be detected by external optical detectors. This type of laser can be used as a new type of imaging modality, in which laser emission in combination with sound waves or ultra-sound waves, is used for imaging Laser emission has a much narrower spectral linewidth and stronger intensity than fluorescence and therefore is able to achieve higher sensitivity, whereas sound waves are used to provide a better spatial resolution of the laser emission from the laser. In ultrasound modulated laser based imaging, multiple lasers can be placed inside cells or tissues.

公开(公告)号：US20230062256A1

公开(公告)日：2023-03-02

申请号：US17795581

申请日：2021-01-28

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Xudong FAN ,  Xueding WANG ,  Xuzhou LI ,  Wei ZHANG ,  William Yanli WANG ,  Xiaoqin WU ,  Xiaotian TAN ,  Brendon BAKER ,  Yannis M. PAULUS

IPC分类号： A61B3/12 ,  G01N33/58 ,  A61B3/10 ,  G01N21/47 ,  G01N21/64

摘要： An imaging system for cell-based therapies is provided. The imagining system includes one or more optical tags configured for insertion into a cell or biological tissue, an excitation light source configured to illuminate the one or more optical tags; a detector configured to measure optical emission of the one or more optical tags; an imaging subsystem configured to determine a three-dimensional location of each of the one or more optical tags in the cell or biological tissue; and a controller in electrical communication with the excitation light source, the detector, and the imaging subsystem. Each of the one or more optical tags has a contrasting feature and includes a fluorescent material. The contrasting feature may be defined by at least one of a refractive index, shape, color, and laser emission of each optical tag of the one or more optical tags.