公开(公告)号：US20180344729A1

公开(公告)日：2018-12-06

申请号：US15778207

申请日：2016-12-02

Applicant: THE SCRIPPS RESEARCH INSTITUTE ,  LEIDEN UNIVERSITY

Inventor： Benjamin F. CRAVATT ,  Daisuke OGASAWARA ,  Andreu VIADER ,  Hui DENG ,  Tom VAN DER WEL ,  Marcelis VAN DER STELT

IPC: A61K31/496 ,  A61K31/454 ,  A61K31/4439 ,  A61K31/4192 ,  A61K31/506

CPC classification number: A61K31/496 ,  A61K31/4192 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/506 ,  A61P25/28 ,  C07D401/06 ,  C07D401/14 ,  C07D405/14 ,  C07D513/12

Abstract: Provided herein are triazole compounds and pharmaceutical compositions comprising said compounds useful as modulators of DAGL(α) and DAGL(β). In some embodiments, the compounds described herein are selective DAGL(α) inhibitors. Furthermore, the subject compounds and compositions are useful for the treatment of neurodegenerative or neuroinflammatory disease.

公开(公告)号：US20250034216A1

公开(公告)日：2025-01-30

申请号：US18712449

申请日：2022-11-21

Applicant: The Scripps Research Institute

Inventor： Benjamin CRAVATT ,  Jarrett REMSBERG ,  Michael LAZEAR ,  Minoru YOKOYAMA ,  Michael SCHAFROTH ,  Daisuke OGASAWARA ,  Kristen DEMEESTER ,  Evert NJOMEN ,  Bruno MELILLO ,  Stuart SCHREIBER

IPC: C07K14/47

Abstract: Provided are in vivo engineered proteins. The engineered protein may be covalently bound to a ligand.

公开(公告)号：US20210221790A1

公开(公告)日：2021-07-22

申请号：US17055081

申请日：2019-05-14

Applicant: THE SCRIPPS RESEARCH INSTITUTE

Inventor： Daisuke OGASAWARA ,  Taka-Aki ICHU ,  Jonathan HULCE ,  Benjamin F. CRAVATT

IPC: C07D401/14 ,  C07D401/12 ,  C07D471/08 ,  C07D471/04 ,  C07D401/04

Abstract: Provided herein are compounds and compositions useful as modulators of ABHD12. Furthermore, the subject compounds and compositions are useful as immunotherapies in treating, for instance, cancer or infectious diseases.