公开(公告)号：US20210316009A1

公开(公告)日：2021-10-14

申请号：US17273059

申请日：2019-09-13

Applicant: THE SECRETARY OF STATE FOR DEFENCE ,  THE UNIVERSITY OF STRATHCLYDE

Inventor： ETHEL DIANE WILLIAMSON ,  RICCARDO VINCENZO D'ELIA ,  CRAIG WILLIAM ROBERTS ,  STUART WOODS

IPC: A61K47/69 ,  A61K9/127 ,  A61K47/14 ,  A61K47/28 ,  A61K47/24 ,  A61K47/42 ,  A61K47/26 ,  A61K31/65 ,  A61K31/5383 ,  A61K31/496 ,  A61K38/21 ,  A61K31/513 ,  A61K31/711 ,  C07K16/10 ,  A61P31/14 ,  A61P31/04 ,  A61K47/54

Abstract: The invention relates to methods for the preparation of a pharmaceutical-vesicle formulation comprising steps of: preparing and processing vesicle components and a pharmaceutical agent to entrap the pharmaceutical agent in the vesicle and form a pharmaceutical-vesicle formulation, wherein the pharmaceutical-vesicle formulation is reconstituted in a known quantity of the pharmaceutical agent dissolved in a pharmaceutically-acceptable carrier to provide a biphasic pharmaceutical-vesicle formulation. The invention also relates to the associated pharmaceutical-vesicle formulations, pharmaceutical kits and uses as a medicament, in particular for the prevention or treatment of infection by bacteria such as Burkholderia pseudomallei and Francisella tularensis, and viruses such as Venezuelan Equine Encephalitis Virus (VEEV).