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公开(公告)号：US11459396B2
公开(公告)日：2022-10-04
申请号：US16465975
申请日：2017-12-01
Applicant: THE TEXAS A&M UNIVERSITY SYSTEM
Abstract: The present disclosure includes a fusion protein, called a “Seldeg”, including a targeting component that specifically binds to a cell surface receptor or other cell surface molecule at near-neutral pH, and an antigen component fused directly or indirectly to the targeting component. The antigen component is configured to specifically bind a target antigen-specific antibody. The present disclosure also includes a method of depleting a target antigen-specific antibody from a patient by administering to the patient a Seldeg having an antigen component configured to specifically bind the target antigen-specific antibody.
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公开(公告)号：US11690919B2
公开(公告)日：2023-07-04
申请号：US16478821
申请日：2018-01-17
Applicant: THE TEXAS A&M UNIVERSITY SYSTEM
Inventor： Elizabeth Sally Ward Ober , Raimund Johannes Ober , Jeffrey Che-Wei Kang , Wei Sun , Ran Li
CPC classification number: A61K47/6855 , A61K47/6817 , A61P35/00 , C07K16/32 , A61K38/00
Abstract: Endolysosomal targeting conjugates that are engineered to deliver cargo molecules such as cytotoxic drugs or imaging labels with improved efficiency to late endosomes and/or lysosomes in target cells such as tumor cells are described. The endolysosomal targeting conjugate includes a targeting component and a cargo component. The targeting component is configured to bind to a cell surface molecule of a target cell and the cargo component includes a cargo molecule. The targeting component and the cargo component may be fused by a covalent bond or associated by a non-covalent bond. The targeting component may bind to the cell surface molecule or the cargo component with higher affinity in the extracellular space than in an endolysosomal compartment of the target cell.
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