公开(公告)号：US11459396B2

公开(公告)日：2022-10-04

申请号：US16465975

申请日：2017-12-01

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： Elizabeth Sally Ward Ober ,  Venkata Siva Charan Devanaboyina ,  Raimund Johannes Ober

IPC: C07K16/28 ,  A61K38/00 ,  C07K14/71 ,  A61K51/10

Abstract: The present disclosure includes a fusion protein, called a “Seldeg”, including a targeting component that specifically binds to a cell surface receptor or other cell surface molecule at near-neutral pH, and an antigen component fused directly or indirectly to the targeting component. The antigen component is configured to specifically bind a target antigen-specific antibody. The present disclosure also includes a method of depleting a target antigen-specific antibody from a patient by administering to the patient a Seldeg having an antigen component configured to specifically bind the target antigen-specific antibody.

公开(公告)号：US20230087965A1

公开(公告)日：2023-03-23

申请号：US17930545

申请日：2022-09-08

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： Elizabeth Sally Ward OBER ,  Venkata Siva Charan Devanaboyina ,  Raimund Johannes Ober

IPC: C07K16/28 ,  C07K14/71

Abstract: The present disclosure includes a fusion protein, called a “Seldeg”, including a targeting component that specifically binds to a cell surface receptor or other cell surface molecule at near-neutral pH, and an antigen component fused directly or indirectly to the targeting component. The antigen component is configured to specifically bind a target antigen-specific antibody. The present disclosure also includes a method of depleting a target antigen-specific antibody from a patient by administering to the patient a Seldeg having an antigen component configured to specifically bind the target antigen-specific antibody.