公开(公告)号：US20240350669A1

公开(公告)日：2024-10-24

申请号：US18762799

申请日：2024-07-03

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： Stavroula KOUSTENI ,  Marta GALÁN-DÍEZ

IPC: A61K48/00 ,  A61K31/4245 ,  A61P35/02 ,  C07K16/18 ,  C12N9/22 ,  C12N15/11 ,  C12N15/113

CPC classification number: A61K48/005 ,  A61K31/4245 ,  A61P35/02 ,  C07K16/18 ,  C12N9/22 ,  C12N15/111 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/20 ,  C12Y113/11052

Abstract: Methods and compositions for treating leukemia involving administering a therapeutically effective amount of an inhibitor of indoleamine 2,3 dioxygenase (IDO1). The leukemia may be is acute myeloid leukemia or acute lymphoid leukemia. The inhibitor can be a small molecule such as indiximod, epacadostat, BMS-986205, navoximod, PF-0684003, KHK2455 or LY3381916 or epacadostat. The inhibitor can be used alone or in conjunctions with other chemotherapeutic agents. IDO1 can also be inhibited using a CRISP-CAS system. The inhibitor can be administered orally, intravenously, intramuscularly, topically, arterially, or subcutaneously.