公开(公告)号：US11020617B2

公开(公告)日：2021-06-01

申请号：US16265827

申请日：2019-02-01

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Elisa E. Konofagou ,  Matthew Downs ,  Stephen Lee ,  Min Gon Kim ,  Hermes Arytto Salles Kamimura

IPC分类号： A61N7/00 ,  A61B5/00 ,  A61B8/00 ,  A61B8/14 ,  A61N7/02 ,  A61B5/369 ,  A61B5/389 ,  A61B5/024 ,  A61B5/01

摘要： Techniques for modulating peripheral nerves using focused ultrasound (FUS) are provided. Methods include locating a peripheral nerve in a subject using an imaging probe, providing a FUS having one or more ultrasound parameters to a location on the peripheral nerve, and modulating the peripheral nerve. The methods can further include eliciting and measuring a physiological response from the FUS modulation, generating tissue deformation in the vicinity of the FUS modulation, and imaging the nerve and the tissue deformation simultaneously with FUS modulation. Systems for use in the modulation of peripheral nerves are also provided.

公开(公告)号：US20200147415A1

公开(公告)日：2020-05-14

申请号：US16742568

申请日：2020-01-14

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Elisa E. Konofagou ,  Matthew Downs ,  Stephen Lee ,  Min Gon Kim ,  Hermes Arytto Salles Kamimura

IPC分类号： A61N7/02 ,  A61B5/0488

摘要： Techniques for selective modulation of motor neuronal activity in a peripheral nervous system using a focused ultrasound assembly are provided. Methods include adjusting a pulse repetition frequency parameter of a focused ultrasound to selectively modulate a location on a peripheral nerve and modulating the peripheral nerve with the focused ultrasound to increase a temperature of the peripheral nerve. The modulating can comprise one or more of exciting and inhibiting the peripheral nerve with the focused ultrasound, either separately or in combination. Methods can further include locating the peripheral nerve using an imaging probe, monitoring a physiological response to the modulating, and changing the one or more ultrasound parameters in response to the physiological response. Systems for use in the modulation of peripheral nerves are also provided.

公开(公告)号：US20190247678A1

公开(公告)日：2019-08-15

申请号：US16265827

申请日：2019-02-01

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Elisa E. Konofagou ,  Matthew Downs ,  Stephen Lee ,  Min Gon Kim ,  Hermes Arytto Salles Kamimura

IPC分类号： A61N7/00 ,  A61B5/0488 ,  A61B5/00 ,  A61B8/14 ,  A61B8/00 ,  A61B5/0476

CPC分类号： A61N7/00 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/4836 ,  A61B8/14 ,  A61B8/42 ,  A61N2007/0026

摘要： Techniques for modulating peripheral nerves using focused ultrasound (FUS) are provided. Methods include locating a peripheral nerve in a subject using an imaging probe, providing a FUS having one or more ultrasound parameters to a location on the peripheral nerve, and modulating the peripheral nerve. The methods can further include eliciting and measuring a physiological response from the FUS modulation, generating tissue deformation in the vicinity of the FUS modulation, and imaging the nerve and the tissue deformation simultaneously with FUS modulation. Systems for use in the modulation of peripheral nerves are also provided.