专利检索 ap:("THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK" OR "Massachusetts Institute of Technology" OR "The Broad Institute, Inc.") AND inv:"Pratiksha THAKORE" 第 1 页

1.

发明公开
COMPOSITIONS AND METHODS FOR MODULATING CANCER IMMUNE FITNESS 审中-公开

公开(公告)号：US20240294643A1

公开(公告)日：2024-09-05

申请号：US18430961

申请日：2024-02-02

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , Massachusetts Institute of Technology , The Broad Institute, Inc.

发明人： Benjamin IZAR , Johannes C. MELMS , Pratiksha THAKORE , Katie GEIGER-SCHULLER , Aviv REGEV , Chris FRANGIEH

IPC分类号： C07K16/28 , A61K31/7105 , A61K45/06 , C12N15/113 , C12N15/115

CPC分类号： C07K16/2824 , A61K31/7105 , A61K45/06 , C12N15/1138 , C12N15/115 , C07K2317/76 , C12N2310/14

摘要： Methods of targeting CD58 signaling to enhance antitumor immunity and overcome resistance to checkpoint blockade therapy. Gene signatures associated with immune fitness were identified. Markers and therapeutic targets for such immunotherapy resistance.