公开(公告)号：US20200369773A1

公开(公告)日：2020-11-26

申请号：US16639836

申请日：2018-08-20

Applicant: CELDARA MEDICAL LLC ,  THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Michael Whitfield ,  Patricia Pioli ,  Charles Sentman ,  Jake Reder ,  Joana Murad ,  Yolanda Nesbeth

IPC: C07K16/28 ,  A61K35/17

Abstract: The invention provides chimeric antigen receptors (CARs), nucleic acid sequences encoding a CAR, vectors comprising a nucleic acid sequence encoding a CAR, cells expressing a CAR, pharmaceutical compositions comprising a cell expressing a CAR, wherein the CAR binds to a target molecule expressed on disease-associated macrophages or over- or aberrantly-expressed in fibrosis. The invention further provides vectors encoding a CAR and a fibrotic disease-modulatory molecule (FDMM), and cells expressing both a CAR and an FDMM. The invention also provides methods of treating a subject using a CAR, a nucleic acid sequence, a vector or vectors, or a CAR-expressing cell, a cell expressing both a CAR and an FDMM, or a pharmaceutical composition, and to methods of generating a CAR-expressing cell or a cell expressing both a CAR and an FDMM. The invention also provides methods of treating diseases, fibrotic conditions, inflammatory conditions, autoimmune conditions, and conditions associated with disease-associated macrophages (DAMs).

公开(公告)号：US11857571B2

公开(公告)日：2024-01-02

申请号：US16994795

申请日：2020-08-17

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Charles Sentman ,  Michael Battles

IPC: A61K35/17 ,  C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  A61K51/10 ,  A61K39/00

CPC classification number: A61K35/17 ,  A61K47/6835 ,  A61K51/1045 ,  A61K51/1096 ,  A61P35/00 ,  C07K16/2809 ,  C07K16/2833 ,  C07K16/2851 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2319/03

Abstract: Antigen binding fragments, chimeric antigen receptors, and bi-specific T-cell engagers having specificity for MICA and methods for using the same in the diagnosis and treatment of disorders associated with MICA and/or MICB expression are provided.

公开(公告)号：US10744157B2

公开(公告)日：2020-08-18

申请号：US15561748

申请日：2016-03-25

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Charles Sentman ,  Michael Battles

IPC: C07K16/28 ,  A61K35/17 ,  A61K47/68 ,  A61P35/00 ,  A61K51/10 ,  A61K39/00

Abstract: Antigen binding fragments, chimeric antigen receptors, and bi-specific T-cell engagers having specificity for MICA and methods for using the same in the diagnosis and treatment of disorders associated with MICA and/or MICB expression are provided.