公开(公告)号：US10954315B2

公开(公告)日：2021-03-23

申请号：US15814201

申请日：2017-11-15

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Chenfeng Ke ,  Qianming Lin

IPC: C08G83/00 ,  C08B37/16 ,  C08L71/02 ,  A61L27/26 ,  A61L15/60 ,  A61L15/22 ,  A61K47/69 ,  B33Y70/00 ,  A61L27/52 ,  A61L26/00 ,  C08J3/075 ,  C08G65/332 ,  C08J3/24 ,  B33Y80/00 ,  A61L27/18 ,  B33Y10/00 ,  A61L27/20 ,  A61L15/26 ,  A61L15/28 ,  A61K9/00 ,  A61K9/06

Abstract: Provided are supramolecular polypseudorotaxane hydrogel compositions and 3-D structures capable of reversible 3-D structural deformation which include (a) a solvent; (b) an at least partially linear polymer, where the polymer further comprises groups capable of covalent crosslinking between the polymers; (ii) at least one first macrocyclic ring which forms a pseudorotaxane with a polymer in the polymer network; and (iii) at least one second macrocyclic ring that does not form the pseudorotaxane. The hydrogel composition has a viscosity which allows for 3-D printing of the hydrogel to form a 3-D structure, and a storage (elastic) modulus after crosslinking that allows for the 3-D structure to undergo reversible 3-D structural deformation upon change of solvent conditions. Also provided are methods of manufacturing the compositions and 3-D structures.

公开(公告)号：US20190144569A1

公开(公告)日：2019-05-16

申请号：US15814201

申请日：2017-11-15

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Chenfeng Ke ,  Qianming Lin

IPC: C08B37/16 ,  C08G83/00 ,  C08L71/02 ,  A61L27/26 ,  A61L27/52 ,  A61L15/60 ,  A61L15/22 ,  A61K47/69 ,  B33Y70/00

Abstract: Provided are supramolecular polypseudorotaxane hydrogel compositions and 3-D structures capable of reversible 3-D structural deformation which include (a) a solvent; (b) an at least partially linear polymer, where the polymer further comprises groups capable of covalent crosslinking between the polymers; (ii) at least one first macrocyclic ring which forms a pseudorotaxane with a polymer in the polymer network; and (iii) at least one second macrocyclic ring that does not form the pseudorotaxane. The hydrogel composition has a viscosity which allows for 3-D printing of the hydrogel to form a 3-D structure, and a storage (elastic) modulus after crosslinking that allows for the 3-D structure to undergo reversible 3-D structural deformation upon change of solvent conditions. Also provided are methods of manufacturing the compositions and 3-D structures.