公开(公告)号：US20170056331A1

公开(公告)日：2017-03-02

申请号：US14680710

申请日：2015-04-07

Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY

Inventor： Howard A. STONE ,  Janine K. NUNES ,  Eujin UM ,  Tamara PICO

IPC: A61K9/70 ,  A61K47/36 ,  A61K31/085 ,  A61K49/00 ,  A61K35/33 ,  A61K35/74

CPC classification number: A61K31/085 ,  A61K9/0092 ,  A61K9/5026 ,  A61K49/0043 ,  A61K49/0093 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/62

Abstract: The invention includes microfluidic methods and devices that allow for the continuous production of microfibers with embedded droplets aligned along the length of the fiber at specific positions. The invention allows for formation of single or multiple emulsions within a fiber. The various phases comprised within the fiber can vary in terms of in terms of hydrophobic/hydrophilic character, solid/fluid, or gel crosslink density, which allows for the introduction of heterogeneous microenvironments within the fiber, each of which with distinct solubility characteristics, permeability, and mechanical properties. Various compounds and materials can be encapsulated in the different microcompartments of the fiber for storage and delivery applications, as well as to provide multifunctionality to the fiber structure. The disclosed structures have a broad range of potential applications, for example as engineered substrates with controlled release profiles of multiple compounds for tissue engineering (such as a tissue scaffold, for example) and bioengineering applications.

Abstract translation: 本发明包括微流体方法和装置，其允许连续生产具有沿特定位置的纤维长度对齐的嵌入液滴的微纤维。 本发明允许在纤维内形成单个或多个乳液。 包含在纤维中的各种相可以根据疏水性/亲水特性，固体/流体或凝胶交联密度而变化，这允许在纤维内引入异质微环境，其中每一种具有不同的溶解度特性，渗透性 ，和机械性能。 可以将各种化合物和材料包封在纤维的不同微型隔室中用于储存和递送应用，以及为纤维结构提供多功能性。 所公开的结构具有广泛的潜在应用，例如作为具有用于组织工程的多种化合物（例如组织支架）和生物工程应用的受控释放特征的工程化基底。