专利检索 ap:("THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN") AND inv:"Zongyi Hu" 第 1 页

1.

发明申请
PIPERIDINE AND PIPERAZINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS AND CANCER 审中-公开
标题翻译：哌啶和哌嗪衍生物及其在治疗病毒感染和癌症中的应用

公开(公告)号：US20170001988A1

公开(公告)日：2017-01-05

申请号：US15039781

申请日：2014-11-20

申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN

发明人： Tsanyang Jake Liang , Marc Ferrer , Shanshan He , Xin Hu , Zongyi Hu , Juan Jose Marugan , Noel Terrence Southall , Jingbo Xiao , Wei Zheng

IPC分类号： C07D405/10 , A61K31/55 , A61K45/06 , C07D211/58 , A61K31/453 , A61K31/4468 , C07D295/073 , A61K31/495 , C07D213/16 , A61K31/4409 , A61K31/4465 , C07D211/12 , C07D295/03 , C07D211/14 , C07D403/12 , A61K31/496 , C07D243/08

CPC分类号： C07D405/10 , A61K31/4409 , A61K31/4465 , A61K31/4468 , A61K31/453 , A61K31/495 , A61K31/496 , A61K31/55 , A61K45/06 , C07D209/48 , C07D211/12 , C07D211/14 , C07D211/58 , C07D213/16 , C07D243/08 , C07D295/03 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/185 , C07D403/12

摘要： Disclosed are compounds of formula (I) (formula I), as antiviral agents, antineoplastic agents, pharmaceutical compositions comprising such compounds, and a method of use of these compounds, wherein X and Y are independently CH or N, o is 0, 1 or 2, and E is absent or is (CR13R14)m, NH, or S, F is absent or is (CR15R16)n, C=O, or —SO2—, G is absent or is (CR17 CR18)r, H is absent or is C═O, or —SO2- and R1, Ar1, Ar2 are as defined in the specification. These compounds are antiviral agents and are contemplated in the treatment of viral infections, for example, hepatitis C, or are antineoplastic agents.

摘要翻译： 公开了式（I）（式I）的化合物，作为抗病毒剂，抗肿瘤剂，包含这些化合物的药物组合物和这些化合物的使用方法，其中X和Y独立地是CH或N，O是0,1 或（2），E不存在或为（CR 13 R 14）m，NH或S，F不存在或为（CR 15 R 16）n，C = O或-SO 2 - ，G不存在或为（CR 17 CR 18）r ，H不存在或C = O或-SO 2 - ，且R 1，Ar 1，Ar 2如说明书中所定义。这些化合物是抗病毒剂，并且被考虑用于治疗病毒感染，例如丙型肝炎，或是抗肿瘤剂。