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1.发明公开公开(公告)号：US20240316056A1
公开(公告)日：2024-09-26
申请号：US18735506
申请日：2024-06-06
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services , University of Kansas , Northwestern University
发明人： Udo Rudloff , Serguei Kozlov , Juan Jose Marugan , Sui Huang , Samarjit Patnaik , John C. Braisted , Noel T. Southall , Marc Ferrer , Christopher Dextras , John Haslam , Michael Baltezor
IPC分类号： A61K31/519 , A61K31/7068 , A61K45/06 , A61K47/12 , A61P35/04
CPC分类号： A61K31/519 , A61K31/7068 , A61K45/06 , A61K47/12 , A61P35/04
摘要： Disclosed are pharmaceutical formulations comprising a compound of formula (I):
in which R1, R2, R3, and R4 are as described herein, or a pharmaceutically acceptable salt thereof. Also provided are methods for treating pancreatic adenocarcinoma comprising administration of a compound of formula (I), or a pharmaceutically acceptable salt thereof, and methods of detecting the change in expression levels of one or both of FoxA1 and FoxO6 in a pancreatic adenocarcinoma tumor sample from a mammal, wherein the mammal has been administered a compound of formula (I), or a pharmaceutically acceptable salt thereof.-
公开(公告)号：US12085569B2
公开(公告)日：2024-09-10
申请号：US17940883
申请日：2022-09-08
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Joshua LaBaer , Jie Wang , Ji Qiu , Garrick Wallstrom , Karen Anderson , Jin Park , Jonine Figueroa
IPC分类号： G01N33/574 , C07K16/30 , C12Q1/6886 , G01N33/564 , C12N15/11
CPC分类号： G01N33/57415 , C07K16/3015 , C12Q1/6886 , G01N33/564 , C12N15/11 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).
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公开(公告)号：US20240294665A1
公开(公告)日：2024-09-05
申请号：US18663557
申请日：2024-05-14
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Qiong J. Wang , Zhiya Yu , James C. Yang
IPC分类号： C07K16/30 , A61K35/17 , A61P35/00 , C07K14/705 , C07K14/715 , C07K14/725 , C07K16/28
CPC分类号： C07K16/30 , A61P35/00 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K14/7153 , C07K16/2875 , A61K35/17 , C07K2317/60 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/33
摘要： The invention provides a chimeric antigen receptor (CAR) having antigenic specificity for CD70, the CAR comprising: an antigen binding-transmembrane domain comprising a CD27 amino acid sequence lacking all or a portion of the CD27 intracellular T cell signaling domain; a 4-1BB intracellular T cell signaling domain; a CD3ζ intracellular T cell signaling domain; and optionally, a CD28 intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.
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公开(公告)号：US12071632B2
公开(公告)日：2024-08-27
申请号：US17049916
申请日：2019-04-23
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
IPC分类号： C12N15/86 , A61K39/155 , A61P31/14 , A61K39/00
CPC分类号： C12N15/86 , A61K39/155 , A61P31/14 , A61K2039/5256 , A61K2039/543 , C12N2760/18534 , C12N2760/18544 , C12N2760/18551
摘要： Disclosed are live, chimeric non-human Mononegavirales vectors that allow a cell to express at least one protein from at least one human pathogen. In addition, compositions comprising the vectors, methods and kits for eliciting an immune response in a host, and methods of making the vectors are disclosed, in accordance with embodiments of the invention.
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公开(公告)号：US12059413B2
公开(公告)日：2024-08-13
申请号：US16342695
申请日：2017-10-30
申请人： The Research Foundation for the State University of New York , THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services
发明人： Carol Carter , Lorna Erlich , Nico Tjandra , Madeleine Davison
IPC分类号： A61K31/4439 , G01N33/569
CPC分类号： A61K31/4439 , G01N33/56988
摘要： The present invention provides a method of inhibiting release of a virus from a cell, comprising contacting the cell with a compound that binds an ubiquitin E2 variant (UEV) domain of a cellular polypeptide, or fragment thereof, with an affinity sufficient to inhibit or disrupt the binding of the cellular polypeptide, or fragment thereof, to ubiquitin.
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6.发明授权公开(公告)号：US12043660B2
公开(公告)日：2024-07-23
申请号：US17551066
申请日：2021-12-14
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , The Trustees of Columbia University in the City of New York
发明人： Peter Kwong , Young Do Kwon , Ivelin Georgiev , Gilad Ofek , Baoshan Zhang , Krisha McKee , John Mascola , Mark Connors , Gwo-Yu Chuang , Sijy O'Dell , Robert Bailer , Mark Louder , Mangaiarkarasi Asokan , Richard Schwartz , Jonathan Cooper , Kevin Carlton , Michael Bender , Amarendra Pegu , Lawrence Shapiro , Tatyana Gindin , Lisa Kueltzo
CPC分类号： C07K16/1063 , A61P31/18 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/52 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N2333/162
摘要： Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.
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公开(公告)号：US20240228657A9
公开(公告)日：2024-07-11
申请号：US18471137
申请日：2023-09-20
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
发明人： Ira H. Pastan , Junxia Wei , Masanori Onda , Tapan Bera , Mitchell Ho
CPC分类号： C07K16/30 , C07K14/21 , C07K16/2803 , C07K16/2866 , C07K16/2878 , C07K2317/31 , C07K2317/569 , C07K2317/624 , C07K2317/73 , C07K2317/94 , C07K2319/33 , C07K2319/50 , C07K2319/55 , C07K2319/70
摘要： Disclosed is a molecule comprising: (a) a first domain, which comprises a targeting moiety; (b) a second domain, which comprises an albumin binding domain (ABD), (c) a third domain, which comprises a furin cleavage sequence (“FCS”), which FCS is cleavable by furin; and (d) a fourth domain, which comprises an optionally substituted Domain III from Pseudomonas exotoxin A (“PE”). Related nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, methods of producing the molecule, methods of treating or preventing cancer in a mammal, and methods of inhibiting the growth of a target cell are also disclosed.
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公开(公告)号：US20240209059A1
公开(公告)日：2024-06-27
申请号：US18423020
申请日：2024-01-25
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Eric Tran , Yong-Chen Lu , Anna Pasetto , Paul F. Robbins , Steven A. Rosenberg , Zhili Zheng
IPC分类号： C07K14/725 , A61P35/00 , C07K14/82 , C12N15/85 , G01N33/574
CPC分类号： C07K14/7051 , A61P35/00 , C07K14/82 , C12N15/85 , G01N33/57407 , A61K38/00 , G01N2333/7051
摘要： Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) presented in the context of an HLA-Cw*0802 molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
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公开(公告)号：US12018077B2
公开(公告)日：2024-06-25
申请号：US16912291
申请日：2020-06-25
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
IPC分类号： C07K14/705 , A61K35/17 , A61K39/00 , A61P35/00 , C07K14/725 , C07K16/28 , C07K16/30
CPC分类号： C07K16/2803 , A61K35/17 , A61P35/00 , C07K14/7051 , C07K14/70521 , C07K16/3061 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/70
摘要： The presently disclosed subject matter provides for methods and compositions for treating cancer (e.g., multiple myeloma). It relates to anti-CD56 antibodies, chimeric antigen receptors (CARs) that specifically target human CD56, and immunoresponsive cells comprising such CARs. The presently disclosed CD56-specific CARs have enhanced immune-activating properties, including anti-tumor activity.
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10.发明授权公开(公告)号：US12018051B2
公开(公告)日：2024-06-25
申请号：US18162530
申请日：2023-01-31
发明人： Peter Collins , Bo Liang , Shirin Munir , Anne Schaap Nutt , Ursula Buchholz , Natalie Mackow , Peter Kwong , Barney Graham , Jason McLellan
IPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , A61P31/14 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , A61P31/14 , A61K2039/5254 , A61K2039/5256 , A61K2039/575 , A61K2039/70 , C07K2319/03 , C07K2319/033 , C12N2760/00022 , C12N2760/18534 , C12N2760/18571 , C12N2760/18622 , C12N2760/18634 , C12N2760/18641 , C12N2760/18643 , C12N2760/18671 , C12N2760/18722 , C12N2760/18734 , C12N2760/18741 , C12N2760/18743 , C12N2760/18771
摘要： Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.
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