公开(公告)号：US20160169899A1

公开(公告)日：2016-06-16

申请号：US14903706

申请日：2014-07-11

申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES

发明人： Majda HAZNADAR ,  Ewy MATHE ,  Andrew D. PATTERSON ,  Curtis Craig HARRIS ,  Frank GONZALEZ ,  Kristopher KRAUSZ ,  Soumen MANN

IPC分类号： G01N33/574

CPC分类号： G01N33/57423 ,  G01N33/5743 ,  G01N33/57488 ,  G01N2400/00 ,  G01N2800/52

摘要： The present invention provides methods and materials for diagnosing cancer in an individual using a tissue, blood or urine sample from the patient. Specifically, the disclosed method comprises determining the level of one or more metabolite selected from the group consisting of creatine riboside, metabolite 561+, Cortisol sulfate and N-acetylneuraminic acid. The present invention also provides a method for determining the prognosis of a cancer patient by determining the level of one or more metabolite selected from the group consisting of creatine riboside, metabolite 561+, Cortisol sulfate and N-acetylneuraminic acid. Also provided are kits for detecting cancer or determining the prognosis of a cancer patient.

摘要翻译： 本发明提供了使用来自患者的组织，血液或尿液样本诊断个体癌症的方法和材料。 具体地，所公开的方法包括测定选自肌酸核苷，代谢物561+，硫酸皮质醇和N-乙酰神经氨酸的一种或多种代谢物的水平。 本发明还提供了通过测定选自肌酸核苷，代谢物561+，硫酸皮质醇和N-乙酰神经氨酸的一种或多种代谢物的水平来确定癌症患者的预后的方法。 还提供了用于检测癌症或确定癌症患者的预后的试剂盒。