专利检索 ap:("THE UNIVERSITY OF CHICAGO") AND inv:"Weixin TANG" 第 1 页

1.

发明公开
POLYPEPTIDES AND METHODS FOR MODIFYING NUCLEIC ACIDS 审中-公开

公开(公告)号：US20240352439A1

公开(公告)日：2024-10-24

申请号：US18688268

申请日：2022-09-02

申请人： THE UNIVERSITY OF CHICAGO

发明人： Weixin TANG , Yulan XIAO

IPC分类号： C12N9/78 , C12N9/22 , C12N15/10

CPC分类号： C12N9/78 , C12N9/22 , C12N15/1058 , C12Y305/04004

摘要： The inventors have made TadA variants with improved activities, such as improved based editing in certain genomic contexts and altered editing window. Aspects of the disclosure relate to a polypeptide comprising SEQ ID NO: 1, wherein the polypeptide comprises one or more amino acid substitutions relative to SEQ ID NO: 1, wherein the one or more amino acid substitutions comprise a substitution at amino acid (23, 27, 36, 47, 48, 51, 76, 82, 106, 108, 109,110, 111, 114, 119, 122, 123, 126, 127, 146, 147, 152, 154, 155, 156, 157, 161, 166, 167), and combinations thereof.