公开(公告)号：US12099061B2

公开(公告)日：2024-09-24

申请号：US17237433

申请日：2021-04-22

Applicant: THE UNIVERSITY OF HONG KONG

Inventor： Wai Ping Judy Yam ,  Xiaowen Mao ,  Sze Keong Tey

IPC: G01N33/574 ,  A61K39/00 ,  A61P35/00 ,  C07K16/18 ,  C07K16/28

CPC classification number: G01N33/57438 ,  A61P35/00 ,  C07K16/18 ,  C07K16/2878 ,  A61K2039/505 ,  G01N2333/46 ,  G01N2333/70578

Abstract: The present disclosure provides methods and compositions for treatment, screening, diagnosis and prognosis of hepatocellular carcinoma with extrahepatic metastasis. Provided herein are methods and compositions for treatment, screening, diagnosis and prognosis of metastatic cancers. Also provided are antibodies and compositions for the treatment of cancers. Provided herein is therapeutic target for the treatment of cancers or as a marker for cancers. In particular, the protein represents a biological target against which affinity molecules including therapeutic antibodies, or other pharmaceutical agents, can be made. The disclosure also relates to the use of such affinity molecules for the treatment and/or diagnosis of cancers.