公开(公告)号：US20220172811A1

公开(公告)日：2022-06-02

申请号：US17614265

申请日：2020-05-29

申请人： THE UNIVERSITY OF NEWCASTLE

发明人： Murray CAIRNS ,  William REAY

IPC分类号： G16H20/00 ,  G16B50/10 ,  G16B20/20 ,  G16H10/40 ,  G16H10/20

摘要： Disclosed herein are methods for treating complex disorders in human subjects and for preventing complex disorders in human subjects at risk of developing the disorder, including identifying one or more pharmacologically relevant biological pathways associated with a complex disorder and selecting an agent suitable for the treatment or prevention of the complex disorder. As described herein, the quantification of common variant enrichment in biological pathways with known drug targets provides a means of functionally annotating genome-wide polygenic risk scoring, which provides an indication of an individual's exposure to risk variants that are potentially treatable using existing pharmaceutical agents, dietary supplements or lifestyle interventions.